Dermatology, Venereology and Andrology, Alexandria University Alexandria, Egypt.
Pathology, Alexandria University Alexandria, Egypt.
Sex Med. 2013 Aug;1(1):21-9. doi: 10.1002/sm2.3.
Diabetes mellitus (DM) is a multiorgan disease that leads to neurovascular complications that disturb the normal erectile function.
The aim of the current work was to study the early changes occurring in the level of calcitonin gene-related peptide (CGRP) and histopathological changes in penile tissues of uncontrolled diabetic rats.
This study was carried on 50 adult male Sprague-Dawley rats divided into two main groups: group I (control, n = 10) and group II (diabetic, n = 40). Type I DM was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). The tissue level of CGRP and histopathological examination of rat penises were assessed at 2, 4, 6, and 8 weeks after induction of DM.
CGRP was higher in the diabetic group at 4, 6, and 8 weeks than in the control group. However, endothelial changes and decreased smooth muscles mass started only 2 weeks after induction of DM.
Deterioration of histopathological features of the uncontrolled diabetic rats corporeal tissues is time dependent. Furthermore, vascular changes seem to precede the neurological changes. El-Kamshoushi AAM, Abdallah WI, Helal SF, El Azhary NM, and Hassan EM. A study of the early changes of the level of calcitonin gene-related peptide and histopathology of penises of rats with experimentally induced type I diabetes mellitus by streptozocin. Sex Med 2013;1:21-29.
糖尿病（DM）是一种多器官疾病，可导致神经血管并发症，扰乱正常的勃起功能。
本研究旨在研究未控制的糖尿病大鼠阴茎组织中降钙素基因相关肽（CGRP）水平的早期变化和组织病理学变化。
这项研究共涉及 50 只成年雄性 Sprague-Dawley 大鼠，分为两组：I 组（对照组，n = 10）和 II 组（糖尿病组，n = 40）。通过单次腹腔注射链脲佐菌素（60mg/kg）诱导 1 型糖尿病。在诱导糖尿病后 2、4、6 和 8 周评估大鼠阴茎组织的 CGRP 组织水平和组织病理学检查。
糖尿病组在 4、6 和 8 周时 CGRP 水平高于对照组。然而，内皮变化和减少的平滑肌质量仅在诱导 DM 后 2 周开始出现。
未控制的糖尿病大鼠阴茎组织的组织病理学特征的恶化是时间依赖性的。此外，血管变化似乎先于神经变化。El-Kamshoushi AAM、Abdallah WI、Helal SF、El Azhary NM 和 Hassan EM。通过链脲佐菌素诱导的 1 型糖尿病大鼠研究降钙素基因相关肽水平和阴茎组织病理学的早期变化。性医学 2013；1：21-29。
