Marchevsky Alberto M, Wick Mark R
From the Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California (Dr Marchevsky);
Arch Pathol Lab Med. 2015 Mar;139(3):394-9. doi: 10.5858/arpa.2014-0106-RA. Epub 2014 Oct 30.
Evidence-based medicine has been proposed as a new paradigm for the identification and evaluation of medical information. Best available evidence or data are identified and used as the basis for the diagnosis and treatment of individual patients. Evidence-based pathology has adapted basic evidence-based medicine concepts to the specific needs of pathology and laboratory medicine.
To briefly review the history and basic concepts of evidence-based medicine and evidence-based pathology, describe how to perform and interpret systematic reviews, and discuss how to integrate best evidence into guidelines.
PubMed (National Library of Medicine, Washington, DC) and Web of Science (Thompson Reuters, New York, New York) were used.
Evidence-based pathology provides methodology to evaluate the quality of information published in pathology journals and apply it to the diagnosis of tissue samples and other tests from individual patients. Information is gathered through the use of systematic reviews, using a method that is less biased and more comprehensive than ad hoc literature searches. Published data are classified into evidence levels to provide readers with a quick impression about the quality and probable clinical validity of available information. Best available evidence is combined with personal experience for the formulation of evidence-based, rather than opinion-based, guidelines that address specific practice needs.
循证医学已被提议作为识别和评估医学信息的新范式。最佳可得证据或数据被识别出来，并用作个体患者诊断和治疗的基础。循证病理学已将循证医学的基本概念应用于病理学和检验医学的特定需求。
简要回顾循证医学和循证病理学的历史及基本概念，描述如何进行和解释系统评价，并讨论如何将最佳证据整合到指南中。
使用了美国国立医学图书馆（华盛顿特区）的PubMed和汤森路透（纽约）的Web of Science。
循证病理学提供了评估发表在病理学杂志上的信息质量并将其应用于个体患者组织样本诊断及其他检测的方法。信息通过系统评价来收集，该方法比临时文献检索的偏差更小且更全面。已发表的数据被分类为证据级别，以便为读者提供有关现有信息质量和可能的临床有效性的快速印象。最佳可得证据与个人经验相结合，以制定基于证据而非基于意见的指南，满足特定的实践需求。
