卵巢交界性布伦纳瘤：一例免疫组织化学和分子研究病例报告
Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study.
作者信息
De Cecio Rossella, Cantile Monica, Collina Francesca, Marra Laura, Santonastaso Clemente, Scaffa Cono, Botti Gerardo, Losito Nunzia Simona
机构信息
Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy.
Department of Gynecologic Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy.
出版信息
J Ovarian Res. 2014 Oct 29;7:101. doi: 10.1186/s13048-014-0101-7.
Abstract
BACKGROUND
Borderline Brenner tumor of the ovary is a rare entity characterized by papillary structures with a fibro-vascular core, covered by a transitional epithelium, and by the absence of stromal infiltration. It is associated, by definition, with a benign component of Brenner tumor.
CASE
We report a case of a 68-year-old woman, with a right ovarian mass, whose morphology and immuno-profile were consistent with the diagnosis of a borderline Brenner tumor. Immunohistochemistry carried out on selected markers may help to formulate the diagnosis, more than the molecular analyses.
摘要
背景
卵巢交界性布伦纳瘤是一种罕见的病变，其特征为具有纤维血管核心的乳头状结构，被移行上皮覆盖，且无间质浸润。根据定义，它与布伦纳瘤的良性成分相关。
病例
我们报告一例68岁女性，有右侧卵巢肿块，其形态和免疫表型与交界性布伦纳瘤的诊断相符。对选定标志物进行的免疫组化检查可能比分子分析更有助于做出诊断。
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本文引用的文献
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Eur J Cancer. 2013 Dec;49(18):3839-49. doi: 10.1016/j.ejca.2013.08.011. Epub 2013 Sep 5.
2
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Mod Pathol. 2014 Feb;27(2):231-7. doi: 10.1038/modpathol.2013.142. Epub 2013 Jul 26.
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Int J Gynecol Cancer. 2012 Oct;22(8):1332-6. doi: 10.1097/IGC.0b013e318267db2f.
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Clinicopathological features and immunoprofile of 30 cases of Brenner ovarian tumors.30 例 Brenner 卵巢肿瘤的临床病理特征和免疫表型。
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