Palm Ulrich, Ayache Samar S, Padberg Frank, Lefaucheur Jean-Pascal
Department of Physiology, Henri Mondor Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France; Department of Psychiatry, Psychotherapy and Psychosomatics, Ludwig-Maximilian University Munich, Munich, Germany.
Department of Physiology, Henri Mondor Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France; EA 4391, Nerve Excitability and Therapeutic Team, Faculty of Medicine, Paris Est Créteil University, Créteil, France.
Brain Stimul. 2014 Nov-Dec;7(6):849-54. doi: 10.1016/j.brs.2014.09.014. Epub 2014 Oct 16.
Multiple sclerosis (MS) is a disabling neurological disorder presenting a variety of symptoms which are hard to control by actual drug regimens. Non-invasive brain stimulation (NIBS) techniques have been investigated in the past years for the improvement of several neurologic and psychiatric disorders.
Here, we review the application of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (rTMS, iTBS) and electroconvulsive therapy (ECT) in MS patients.
Articles were searched in common literature databases. Crosslinks were reviewed.
ECT was shown to be efficacious for the treatment of severe psychiatric disorders in 21 case reports. The results of tDCS and TMS for the treatment of depressive symptoms, fatigue, tactile sensory deficit, pain, motor performance, and spasticity were assessed in several studies and showed mixed results.
Overall, data for the treatment of MS with NIBS is sparse regarding TMS and tDCS. Treatment of severe psychiatric disorders with ECT is only reported in single cases. More studies are needed to elucidate the potential role of NIBS in MS treatment.
多发性硬化症（MS）是一种致残性神经疾病，会出现多种症状，现有药物治疗方案难以控制这些症状。在过去几年中，人们对非侵入性脑刺激（NIBS）技术进行了研究，以改善多种神经和精神疾病。
在此，我们综述经颅直流电刺激（tDCS）、重复经颅磁刺激（rTMS、iTBS）和电休克治疗（ECT）在MS患者中的应用。
在常见文献数据库中检索文章。对交叉引用进行了综述。
21例病例报告显示ECT对治疗严重精神疾病有效。多项研究评估了tDCS和TMS治疗抑郁症状、疲劳、触觉感觉障碍、疼痛、运动表现和痉挛的结果，结果不一。
总体而言，关于TMS和tDCS，NIBS治疗MS的数据较少。仅在个别病例中报道了ECT治疗严重精神疾病的情况。需要更多研究来阐明NIBS在MS治疗中的潜在作用。
