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“延迟层级”:华法林、髋部骨折与目标导向护理

"Tiers of delay": warfarin, hip fractures, and target-driven care.

作者信息

Eardley W G P, Macleod K E, Freeman H, Tate A

机构信息

Department of Trauma & Orthopaedics, James Cook University Hospital, Middlesbrough, United Kingdom.

出版信息

Geriatr Orthop Surg Rehabil. 2014 Sep;5(3):103-8. doi: 10.1177/2151458514532469.

Abstract

Anticoagulation reversal is a common cause of operative delay. We sought to establish for the first time the impact this has on best practice tariff (BPT) for patients with hip fracture admitted on warfarin. All patients with hip fracture treated operatively over a 32-month period were reviewed. Basic demographics, time to theater, length of stay, and mortality were recorded for all patients. Independent samples t-tests were used to identify statistically significant differences between patients on warfarin and those not taking the drug. A total of 83 patients were admitted anticoagulated with a mean international normalized ratio of 2.65 and a median time to theater of 49.7 hours. Of these patients, 79% breached BPT, incurring significant financial loss. In the control group, 908 patients took a median 24.5 hours, a 28% breach of BPT (P < .01). Length of stay, Nottingham Hip Fracture Score, and predicted 30-day mortality were similar for both the groups. As well as affecting clinical outcome following hip fracture, delay due to anticoagulation causes considerable loss of BPT. Potential loss of revenue due to delays over the study period was £80 000, inspiring the establishment of an "early trigger" anticoagulation protocol. Although it is accepted that there are limitations to this work, it should raise awareness of the real impact of warfarin on patients with hip fracture both in terms of outcome and for the first time, loss of potential revenue.

摘要

抗凝逆转是手术延迟的常见原因。我们首次试图确定这对华法林治疗的髋部骨折患者的最佳实践收费标准(BPT)有何影响。回顾了在32个月期间接受手术治疗的所有髋部骨折患者。记录了所有患者的基本人口统计学数据、手术时间、住院时间和死亡率。使用独立样本t检验来确定服用华法林的患者与未服用该药物的患者之间的统计学显著差异。共有83例患者入院时处于抗凝状态,平均国际标准化比值为2.65,手术中位时间为49.7小时。在这些患者中,79%违反了BPT,造成了重大经济损失。在对照组中,908例患者的手术中位时间为24.5小时,违反BPT的比例为28%(P <.01)。两组患者的住院时间、诺丁汉髋部骨折评分和预测的30天死亡率相似。除了影响髋部骨折后的临床结果外,抗凝导致的延迟还会造成BPT的大量损失。研究期间因延迟造成的潜在收入损失为8万英镑,这促使制定了一项“早期触发”抗凝方案。尽管人们承认这项工作存在局限性,但它应该提高人们对华法林对髋部骨折患者在结果方面以及首次在潜在收入损失方面的实际影响的认识。

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