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服用抗凝剂患者的股骨近端骨折

Proximal femur fractures in patients taking anticoagulants.

作者信息

Papachristos Ioannis V, Giannoudis Peter V

机构信息

Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, UK.

NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK.

出版信息

EFORT Open Rev. 2020 Oct 26;5(10):699-706. doi: 10.1302/2058-5241.5.190071. eCollection 2020 Oct.

Abstract

Thirty per cent of patients presenting with proximal femoral fractures are receiving anticoagulant treatment for various other medical reasons. This pharmacological effect may necessitate reversal prior to surgical intervention to avoid interference with anaesthesia or excessive peri/post-operative bleeding. Consequently, delay to surgery usually occurs.Platelet inhibitors (aspirin, clopidogrel) either alone or combined do not need to be discontinued to allow acute hip surgery. Platelet transfusions can be useful but are rarely needed.Vitamin K antagonists (VKA, e.g. warfarin) should be reversed in a timely fashion and according to established readily accessible departmental protocols. Intravenous vitamin K on admission facilitates reliable reversal, and platelet complex concentrate (PCC) should be reserved for extreme scenarios.Direct oral anticoagulants (DOAC) must be discontinued prior to hip fracture surgery but the length of time depends on renal function ranging traditionally from two to four days.Recent evidence suggests that early surgery (within 48 hours) can be safe. No bridging therapy is generally recommended.There is an urgent need for development of new commonly available antidotes for every DOAC as well as high-level evidence exploring DOAC effects in the acute hip fracture surgical setting. Cite this article: 2020;5:699-706. DOI: 10.1302/2058-5241.5.190071.

摘要

30%的股骨近端骨折患者因各种其他医学原因正在接受抗凝治疗。这种药理作用可能需要在手术干预前进行逆转,以避免干扰麻醉或围手术期/术后过度出血。因此,手术通常会延迟。单独或联合使用的血小板抑制剂(阿司匹林、氯吡格雷)无需停药即可进行急性髋关节手术。血小板输注可能有用,但很少需要。维生素K拮抗剂(VKA,如华法林)应及时并根据已建立的易于获取的科室方案进行逆转。入院时静脉注射维生素K有助于可靠地逆转,血小板复合浓缩物(PCC)应留作极端情况使用。直接口服抗凝剂(DOAC)在髋部骨折手术前必须停用,但停药时间取决于肾功能,传统上为2至4天。最近的证据表明早期手术(48小时内)可能是安全 的。一般不建议进行桥接治疗。迫切需要开发针对每种DOAC的新的常用解毒剂,以及探索DOAC在急性髋部骨折手术环境中作用的高级证据。引用本文:2020;5:699 - 706。DOI:10.1302/2058 - 5241.5.190071。

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本文引用的文献

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Injury. 2019 Nov;50(11):2040-2044. doi: 10.1016/j.injury.2019.09.011. Epub 2019 Sep 12.
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