Fuchiwaki Yusuke, Tanaka Masato, Makita Yoji, Ooie Toshihiko
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14, Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.
Sensors (Basel). 2014 Oct 30;14(11):20468-79. doi: 10.3390/s141120468.
The present work demonstrates a valuable approach to developing quartz crystal microbalance (QCM) sensor units inexpensively for reliable determination of analytes. This QCM sensor unit is constructed by inkjet printing equipment utilizing background noise removal techniques. Inkjet printing equipment was chosen as an alternative to an injection pump in conventional flow-mode systems to facilitate the commercial applicability of these practical devices. The results demonstrate minimization of fluctuations from external influences, determination of antigen-antibody interactions in an inkjet deposition, and quantification of C-reactive protein in the range of 50-1000 ng∙mL-1. We thus demonstrate a marketable application of an inexpensive and easily available QCM sensor system.
本研究展示了一种经济高效地开发石英晶体微天平（QCM）传感器单元的宝贵方法，用于可靠地测定分析物。这种QCM传感器单元是通过利用背景噪声去除技术的喷墨打印设备构建的。选择喷墨打印设备替代传统流动模式系统中的注射泵，以促进这些实用设备的商业应用。结果表明，该方法可将外部影响引起的波动降至最低，能在喷墨沉积中测定抗原-抗体相互作用，并能对50-1000 ng∙mL-1范围内的C反应蛋白进行定量。因此，我们展示了一种价格低廉且易于获得的QCM传感器系统的市场应用前景。
