一种先天性免疫基因——Toll样受体4的多态性与侵袭性前列腺癌风险：一项系统评价和荟萃分析。
Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.
作者信息
Weng Pei-Hsuan, Huang Yi-Ling, Page John H, Chen Jen-Hau, Xu Jianfeng, Koutros Stella, Berndt Sonja, Chanock Stephen, Yeager Meredith, Witte John S, Eeles Rosalind A, Easton Douglas F, Neal David E, Donovan Jenny, Hamdy Freddie C, Muir Kenneth R, Giles Graham, Severi Gianluca, Smith Jeffrey R, Balistreri Carmela R, Shui Irene M, Chen Yen-Ching
机构信息
Department of Family Medicine, Taiwan Adventist Hospital, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America.
出版信息
PLoS One. 2014 Oct 31;9(10):e110569. doi: 10.1371/journal.pone.0110569. eCollection 2014.
BACKGROUND
Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews.
METHODS
We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls.
RESULTS
Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity.
CONCLUSIONS
TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.
背景
Toll样受体4（TLR4）是最知名的TLR成员之一，表达于多种白细胞和组织细胞表面，在检测病原体和危险相关分子模式中起关键作用。TLR4在几种与年龄相关疾病的病理生理学中的作用也已得到充分认识，如前列腺癌（PCa）。TLR4基因多态性与PCa风险相关，但TLR4基因型与侵袭性PCa风险之间的关系尚未通过任何系统评价进行评估。
方法
我们对分析这种关系的候选基因和全基因组关联研究进行了系统评价和荟萃分析，且仅纳入白人人群。根据适当标准，荟萃分析中仅分析了9项研究，包括3937例侵袭性PCa患者和7382例对照。
结果
采用随机效应模型，在至少4项纳入研究报告的10个TLR4单核苷酸多态性（SNP）中，在任何遗传模型下均未发现显著关联（rs2737191、rs1927914、rs10759932、rs1927911、rs11536879、rs2149356、rs4986790、rs11536889、rs7873784和rs1554973）。另外3项研究报告的10个TLR4 SNP的合并估计值也未显示出显著关联（rs10759930、rs10116253、rs11536869、rs5030717、rs4986791、rs11536897、rs1927906、rs913930、rs1927905和rs7045953）。荟萃回归显示，研究类型不是研究间异质性的显著来源。
结论
TLR4基因多态性与侵袭性PCa风险无显著关联。
Zotero 插件