特利加压素诱发的缺血性皮肤坏死：一种罕见的关联。
Terlipressin-induced ischemic skin necrosis: a rare association.
作者信息
Ozel Coskun Banu Demet, Karaman Ahmet, Gorkem Hasan, Buğday Irfan, Poyrazoğlu Orhan Kursad, Senel Fatma
机构信息
Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Department of Pathology, Kayseri Training and Research Hospital, Kayseri, Turkey.
出版信息
Am J Case Rep. 2014 Oct 31;15:476-9. doi: 10.12659/AJCR.891084.
BACKGROUND
Terlipressin is a synthetic vasopressin analogue that is used in the treatment of bleeding esophageal varices and hepatorenal syndrome in patients with cirrhosis. Serious ischemic adverse events, such as skin necrosis involving the extremities, scrotum, trunk, and abdominal skin, are rarely observed. In the literature to date, 20 cases that developed ischemic skin necrosis due to terlipressin usage have been reported.
CASE REPORT
We report a patient with extensive skin necrosis on the infusion site of the right forearm and hand, which developed after the use terlipressin used to treat bleeding oesophageal varices in a 65-year-old man with cirrhosis.
CONCLUSIONS
Although rare, ischemic complications of terlipressin do occur.
背景
特利加压素是一种合成的血管加压素类似物，用于治疗肝硬化患者的食管静脉曲张出血和肝肾综合征。严重的缺血性不良事件，如累及四肢、阴囊、躯干和腹部皮肤的皮肤坏死，很少见。在迄今为止的文献中，已有20例因使用特利加压素而发生缺血性皮肤坏死的病例报道。
病例报告
我们报告了一名65岁肝硬化男性患者，在使用特利加压素治疗食管静脉曲张出血后，右前臂和手部输液部位出现广泛皮肤坏死。
结论
尽管罕见，但特利加压素的缺血性并发症确实会发生。
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