加压素在肝脏疾病中的缺血性并发症：病例系列
Ischaemic complications of Glypressin in liver disease: a case series.
作者信息
Donnellan Fergal, Cullen Garret, Hegarty John E, McCormick P Aiden
机构信息
National Liver Transplant Unit, St Vincent's University Hospital, Dublin, Ireland.
出版信息
Br J Clin Pharmacol. 2007 Oct;64(4):550-2. doi: 10.1111/j.1365-2125.2007.02921.x.
Abstract
AIM
To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).
METHODS
We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so.
RESULTS
Two patients were obese and developed extensive abdominal wall skin necrosis. The third patient had lower limb chronic venous insufficiency and developed extensive necrosis of both lower limbs.
CONCLUSIONS
With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise. Earlier recognition and treatment may lead to improved outcome.
摘要
目的
报告三例使用血管收缩剂特利加压素（可利新）治疗的肝硬化患者发生广泛皮肤坏死的病例。
方法
我们确定了三名发生皮肤坏死的患者，并确定了使其发生风险增加的任何因素。
结果
两名患者肥胖，发生了广泛的腹壁皮肤坏死。第三名患者患有下肢慢性静脉功能不全，双下肢发生了广泛坏死。
结论
随着特利加压素临床应用的增加以及肥胖和非酒精性脂肪性肝病相关肝硬化发病率的上升，这些严重并发症的发生率可能会上升。早期识别和治疗可能会改善预后。
相似文献
1
Ischaemic complications of Glypressin in liver disease: a case series.加压素在肝脏疾病中的缺血性并发症：病例系列
Br J Clin Pharmacol. 2007 Oct;64(4):550-2. doi: 10.1111/j.1365-2125.2007.02921.x.
2
Two observations raising questions about risk factors of cutaneous necrosis induced by terlipressin (Glypressin).两项观察结果引发了关于特利加压素（Glypressin）所致皮肤坏死危险因素的疑问。
Dermatology. 2009;218(4):334-7. doi: 10.1159/000195676. Epub 2009 Jan 21.
3
A case of ischemic skin necrosis after glypressin therapy in liver cirrhosis.一例肝硬化患者使用特利加压素治疗后发生缺血性皮肤坏死的病例。
Korean J Gastroenterol. 2008 Jun;51(6):381-4.
4
Extensive epidermal necrosis due to terlipressin.
Isr Med Assoc J. 2011 Mar;13(3):180-1.
5
Terlipressin infusion induces ischemia of breast skin in a cirrothic patient with hepatorenal syndrome.特利加压素输注导致一名患有肝肾综合征的肝硬化患者出现乳房皮肤缺血。
Dig Liver Dis. 2008 Apr;40(4):304-5. doi: 10.1016/j.dld.2007.11.009. Epub 2007 Dec 21.
6
Ischemic skin necrosis following terlipressin therapy: report of two cases and review of the literature.特利加压素治疗后缺血性皮肤坏死：两例报告并文献复习
Turk J Gastroenterol. 2012;23(6):788-91.
7
Telipressin induced peripheral ischaemic gangrene and skin necrosis.
Trop Gastroenterol. 2010 Jul-Sep;31(3):229-30.
8
[Extensive cutaneous necrosis due to terlipressin use].
Gastroenterol Hepatol. 2015 Jan;38(1):12-3. doi: 10.1016/j.gastrohep.2014.03.014. Epub 2014 May 16.
9
Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome.特利加压素治疗肝肾综合征导致严重缺血性肠坏死。
Clin Mol Hepatol. 2013 Dec;19(4):417-20. doi: 10.3350/cmh.2013.19.4.417. Epub 2013 Dec 28.
10
Sildenafil in severe peripheral ischemia induced by terlipressin. A case report.西地那非治疗特利加压素所致严重外周缺血：一例报告
Reumatol Clin. 2011 Jan-Feb;7(1):59-60. doi: 10.1016/j.reuma.2010.05.005. Epub 2010 Dec 17.
引用本文的文献
1
From Pathophysiology to Practice: Evolving Pharmacological Therapies, Clinical Complications, and Pharmacogenetic Considerations in Portal Hypertension.从病理生理学到临床实践：门静脉高压症不断发展的药物治疗、临床并发症及药物遗传学考量
Metabolites. 2025 Jan 23;15(2):72. doi: 10.3390/metabo15020072.
2
Terlipressin-induced skin necrosis in cirrhotic patients-A case report and comprehensive literature review.特利加压素诱发肝硬化患者皮肤坏死——一例报告及文献综述
Clin Case Rep. 2024 Sep 29;12(10):e9141. doi: 10.1002/ccr3.9141. eCollection 2024 Oct.
3
OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis.大鼠和非人类灵长类动物体内的OCE - 205：药代动力学和药效学分析。
Curr Res Pharmacol Drug Discov. 2023 Aug 9;5:100163. doi: 10.1016/j.crphar.2023.100163. eCollection 2023.
4
OCE-205, A Novel, Selective Vasopressin Receptor Mixed Agonist-Antagonist: Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics from a Phase 1 Study in Healthy Volunteers.OCE-205，一种新型的选择性血管加压素受体混合激动剂-拮抗剂：来自健康志愿者的 1 期研究的安全性、耐受性和药代动力学/药效学。
Clin Drug Investig. 2023 Sep;43(9):709-717. doi: 10.1007/s40261-023-01299-y. Epub 2023 Aug 22.
5
OCE-205, a Selective V1a Partial Agonist, Reduces Portal Pressure in Rat Models of Portal Hypertension.OCE - 205，一种选择性V1a部分激动剂，可降低门静脉高压大鼠模型的门静脉压力。
J Exp Pharmacol. 2023 Jul 13;15:279-290. doi: 10.2147/JEP.S416673. eCollection 2023.
6
Terlipressin-induced ischaemic skin necrosis.特利加压素诱导的缺血性皮肤坏死。
BMJ Case Rep. 2020 Jan 15;13(1):e233089. doi: 10.1136/bcr-2019-233089.
7
: an unusual adverse reaction to terlipressin.
Ann Gastroenterol. 2017;30(6):700-703. doi: 10.20524/aog.2017.0158. Epub 2017 May 11.
8
Safety and Efficacy of Terlipressin in Pediatric Distributive Shock: A Retrospective Analysis in 20 Children.特利加压素治疗小儿分布性休克的安全性和有效性：20例患儿的回顾性分析
Paediatr Drugs. 2017 Feb;19(1):35-41. doi: 10.1007/s40272-016-0199-8.
9
Terlipressin-induced ischemic skin necrosis: a rare association.特利加压素诱发的缺血性皮肤坏死：一种罕见的关联。
Am J Case Rep. 2014 Oct 31;15:476-9. doi: 10.12659/AJCR.891084.
10
Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome.特利加压素治疗肝肾综合征导致严重缺血性肠坏死。
Clin Mol Hepatol. 2013 Dec;19(4):417-20. doi: 10.3350/cmh.2013.19.4.417. Epub 2013 Dec 28.
本文引用的文献
1
Terlipressin-related acute myocardial infarction: a case report and literature review.特利加压素相关急性心肌梗死：一例病例报告及文献综述
Kaohsiung J Med Sci. 2004 Dec;20(12):604-8. doi: 10.1016/S1607-551X(09)70266-9.
2
Review article: pharmacological treatment of hepatorenal syndrome.综述文章：肝肾综合征的药物治疗
Aliment Pharmacol Ther. 2004 Sep;20 Suppl 3:57-62; discussion 63-4. doi: 10.1111/j.1365-2036.2004.02115.x.
3
Is spontaneous bacterial peritonitis an inducer of vasopressin analogue side-effects? A case report.自发性细菌性腹膜炎是血管加压素类似物副作用的诱发因素吗？一例病例报告。
Dig Liver Dis. 2003 Jul;35(7):503-6. doi: 10.1016/s1590-8658(03)00225-1.
4
Microvascular changes in venous disease: an update.
Angiology. 1997 Jan;48(1):27-32. doi: 10.1177/000331979704800105.
5
Microvascular changes in chronic venous insufficiency--a review.
Cardiovasc Surg. 1995 Jun;3(3):237-45. doi: 10.1016/0967-2109(95)93871-l.
6
A method for estimating the probability of adverse drug reactions.一种估算药物不良反应概率的方法。
Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.
7
[Ischemia of the cecum caused by glycylpressin].[甘氨加压素引起的盲肠缺血]
Leber Magen Darm. 1985 Jul;15(4):165-8.
8
Ischaemic colitis in a patient treated with glypressin for bleeding oesophageal varices.
Hepatogastroenterology. 1987 Jun;34(3):134-6.
Zotero 插件