帕金森病患者苍白球的内部结构：定量磁化率映射（QSM）评估。
Internal structures of the globus pallidus in patients with Parkinson's disease: evaluation with quantitative susceptibility mapping (QSM).
机构信息
Department of Radiology, University of Occupational and Environmental Health School of Medicine, Iseigaoka 1-1, Yahatanishi-ku, Kitakyusyu-shi, 807-8555, Japan,
出版信息
Eur Radiol. 2015 Mar;25(3):710-8. doi: 10.1007/s00330-014-3472-7. Epub 2014 Nov 1.
OBJECTIVES
The aim of this study was to assess the susceptibility change in medial and lateral globus pallidus (GPm and GPl) related to age separately, using quantitative susceptibility mapping (QSM) and to determine whether QSM can depict GPm in Parkinson's disease (PD) patients.
METHODS
QSM was performed in 19 PD patients and in 41 normal control (NC) subjects. First, we quantitatively analysed age-related changes in QSM value in NC for GPl and GPm by a manual region of interest (ROI) technique. Then, in PD patients and age-matched NC subjects, we evaluated the depiction of GPm on QSM images qualitatively.
RESULTS
In NC, the QSM value within GPl significantly increased gradually with age (r = 0.32, p = 0.04), whereas it did not change with age in GPm. The average QSM value was significantly larger for GPl than for GPm (205 vs 191, p < 0.05). In both PD patients and age-matched NC, the depiction of GPm on QSM images was good in most cases (87 %, 33 of 38 sides in PD patients) mainly because of the differences in susceptibility between GPm and GPl.
CONCLUSIONS
The QSM value in GPl increases gradually with age, which allows for the identification of GPm in elderly PD subjects.
目的
本研究旨在使用定量磁化率映射（QSM）分别评估内侧和外侧苍白球（GPm 和 GPl）与年龄相关的敏感性变化，并确定 QSM 是否可以描绘帕金森病（PD）患者的 GPm。
方法
对 19 名 PD 患者和 41 名正常对照（NC）受试者进行了 QSM 检查。首先，我们通过手动感兴趣区（ROI）技术对 NC 中与年龄相关的 GPl 和 GPm 的 QSM 值进行定量分析。然后，在 PD 患者和年龄匹配的 NC 受试者中，我们对 QSM 图像上 GPm 的定性描绘进行了评估。
结果
在 NC 中，GPl 内的 QSM 值随年龄逐渐显著增加（r=0.32，p=0.04），而 GPm 内的 QSM 值随年龄变化不显著。GPl 的平均 QSM 值明显大于 GPm（205 比 191，p<0.05）。在 PD 患者和年龄匹配的 NC 中，QSM 图像上 GPm 的描绘在大多数情况下都很好（87%，33 例 38 侧 PD 患者），这主要是由于 GPm 和 GPl 之间的磁化率差异所致。
结论
GPl 中的 QSM 值随年龄逐渐增加，这使得在老年 PD 患者中可以识别 GPm。
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