Department of System Neuroscience, Division of Cerebral Integration, National Institute for Physiological Sciences (NIPS), 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan.
Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Shonan Village, Hayama, Kanagawa, 240-0193, Japan.
Sci Rep. 2019 Dec 4;9(1):18357. doi: 10.1038/s41598-019-54880-x.
The success of deep brain stimulation (DBS) targeting the internal globus pallidus (GPi) depends on the accuracy of electrode localization inside the GPi. In this study, we sought to compare visualization of the medial medullary lamina (MML) and accessory medullary lamina (AML) between proton density-weighted (PDW) and T2-weighted (T2W) sequences on 3T and 7T MRI scanners. Eleven healthy participants (five men and six women; age, 19-28 years; mean, 21.5) and one 61-year-old man were scanned using two-dimensional turbo spin-echo PDW and T2W sequences on 3T and 7T MRI scanners with a 32-channel receiver head coil and a single-channel transmission coil. Profiles of signal intensity were obtained from the pixel values of straight lines over the GP regions crossing the MML and AML. Contrast ratios (CRs) for GPe/MML, GPie/MML, GPie/AML, and GPii/AML were calculated. Qualitatively, 7T visualized both the MML and AML, whereas 3T visualized the MML less clearly and hardly depicted the AML. The T2W sequence at 7T yielded significantly higher CRs for GPie/MML, GPie/AML, and GPii/AML than the PDW sequence at 7T or 3T. The T2W sequence at 7T allows visualization of the internal structures of GPi segments with high signal intensity and contrast.
深部脑刺激（DBS）靶向内苍白球（GPi）的成功取决于电极在 GPi 内的准确定位。在这项研究中，我们试图比较质子密度加权（PDW）和 T2 加权（T2W）序列在 3T 和 7T MRI 扫描仪上对内侧髓质板（MML）和辅助髓质板（AML）的可视化效果。11 名健康参与者（5 名男性和 6 名女性；年龄 19-28 岁；平均年龄 21.5 岁）和 1 名 61 岁男性使用二维涡轮自旋回波 PDW 和 T2W 序列在 3T 和 7T MRI 扫描仪上进行扫描，使用 32 通道接收器头线圈和单通道传输线圈。从穿过 MML 和 AML 的 GP 区域的直线像素值中获得信号强度曲线。计算苍白球内侧核/ MML、苍白球外侧核/ MML、苍白球外侧核/ AML 和苍白球内侧核/ AML 的对比比（CR）。定性地，7T 可同时显示 MML 和 AML，而 3T 对 MML 的显示不太清晰，几乎无法显示 AML。7T 的 T2W 序列在 GPie/MML、GPie/AML 和 GPii/AML 的 CR 明显高于 7T 或 3T 的 PDW 序列。7T 的 T2W 序列允许以高信号强度和对比度显示 GPi 节段的内部结构。
