胶质母细胞瘤中的干细胞微环境照射：带来一线希望？
Stem cell niche irradiation in glioblastoma: providing a ray of hope?
作者信息
Gupta Tejpal, Nair Vimoj, Jalali Rakesh
机构信息
Department of Radiation Oncology, ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India.
出版信息
CNS Oncol. 2014;3(5):367-76. doi: 10.2217/cns.14.39.
Abstract
Glioblastomas are organized hierarchically with a small number of glioblastoma stem cells that have unique self-renewal capacity and multilineage potency. The subventricular zone (SVZ) constitutes the largest neural stem cell niche in the adult human brain; it may also act as a reservoir of glioblastoma stem cells that can initiate, promote or repopulate a tumor. Incidental irradiation of SVZ has been shown to potentially influence outcomes suggesting that aggressively targeting the stem cell niche may offer a ray of hope in glioblastoma. The following review provides a summary of the experimental evidence supporting the origin and location of the putative glioblastoma stem cell in the SVZ, and offers a critical appraisal of the growing body of clinical evidence correlating SVZ dosimetry with outcomes in glioblastoma.
摘要
胶质母细胞瘤具有层次结构，由少数具有独特自我更新能力和多谱系分化潜能的胶质母细胞瘤干细胞组成。脑室下区（SVZ）是成人大脑中最大的神经干细胞微环境；它也可能充当胶质母细胞瘤干细胞的储存库，这些干细胞可以启动、促进肿瘤生长或使肿瘤重新增殖。已有研究表明，SVZ的意外照射可能会影响治疗结果，这表明积极靶向干细胞微环境可能为胶质母细胞瘤的治疗带来一线希望。以下综述总结了支持SVZ中假定的胶质母细胞瘤干细胞起源和位置的实验证据，并对将SVZ剂量测定与胶质母细胞瘤治疗结果相关联的临床证据进行了批判性评估。
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