Hoogkamp-Korstanje J A, Westerdaal N A
Chemotherapy. 1979;25(1):48-53. doi: 10.1159/000237821.
Of 97 well-defined strains of Pseudomonas, isolated from sputum of patients with cystic fibrosis (CF), the minimum inhibitory concentration (MIC) of several antibiotics was determined with a broth dilution method. The majority of the strains were resistant to ampicillin and cephalothin, moderately susceptible to carbenicillin (70% to 100 microgram/ml) and highly susceptible to piperacillin (100% to 25 microgram/ml, 88% to 6.25 microgram and 60% to 3.12 microgram/ml). If the pharmacological properties of piperacillin are comparable with those of carbenicillin, it can be expected that the sputum level of this drug will be adequate to treat Pseudomonas pulmonary infections. At the lowest concentration tested (0.78 microgram/ml) 3% of the strains were susceptible to kanamycin, 85,5% to amikacin, 95% to gentamicin, 98% of tobramycin, and 80% to colimycin. With regard to clinically attainable concentrations, 98.9% of the strains were susceptible to gentamicin and tobramycin 97.9% to amikacin, 96.9% to colimycin, 88.6% to piperacillin, 38% to carbenicillin, 25.7% to kanamycin, 12.3% to ampicillin, and 1% to cephalothin.
从囊性纤维化（CF）患者痰液中分离出97株明确的假单胞菌菌株，采用肉汤稀释法测定了几种抗生素的最低抑菌浓度（MIC）。大多数菌株对氨苄西林和头孢噻吩耐药，对羧苄西林中度敏感（70%至100微克/毫升），对哌拉西林高度敏感（100%至25微克/毫升、88%至6.25微克和60%至3.12微克/毫升）。如果哌拉西林的药理特性与羧苄西林相当，可以预期该药在痰液中的浓度将足以治疗假单胞菌肺部感染。在测试的最低浓度（0.78微克/毫升）下，3%的菌株对卡那霉素敏感，85.5%对阿米卡星敏感，95%对庆大霉素敏感，98%对妥布霉素敏感，80%对黏菌素敏感。就临床可达到的浓度而言，98.9%的菌株对庆大霉素敏感，97.9%对阿米卡星敏感，96.9%对黏菌素敏感，88.6%对哌拉西林敏感，38%对羧苄西林敏感，25.7%对卡那霉素敏感，12.3%对氨苄西林敏感，1%对头孢噻吩敏感。
