新型氨基糖苷类抗生素和羧苄青霉素单独及联合使用时对庆大霉素耐药铜绿假单胞菌的活性。
Activity of newer aminoglycosides and carbenicillin, alone and in combination, against gentamicin-resistant Pseudomonas aeruginosa.
作者信息
Marks M I, Hammerberg S, Greenstone G, Silver B
出版信息
Antimicrob Agents Chemother. 1976 Sep;10(3):399-401. doi: 10.1128/AAC.10.3.399.
Abstract
The in vitro activity of the aminoglycoside antibiotics tobramycin, sisomicin, amikacin, gentamicin, and netilmicin (SCH 20569) were compared against 26 gentamicin-resistant isolates of Pseudomonas aeruginosa cultured from hospitalized children. Tobramycin had the greatest activity on a weight basis, followed by sisomicin, gentamicin, amikacin, and netilmicin. All isolates were resistant to achievable concentrations of netilmicin and gentamicin, but 23% were inhibited by achievable concentrations of tobramycin, 8% by amikacin, and 4% by sisomicin. The combinations carbenicillin/tobramycin, carbenicillin/sisomicin, and carbenicillin/amikacin were synergistic for 92% of strains; antagonism was not encountered. These in vitro results suggest that tobramycin, sisomicin, or amikacin in combination with carbenicillin would be the safest initial regimen in the therapy of gentamicin-resistant Pseudomonas infections pending susceptibility studies.
摘要
将氨基糖苷类抗生素妥布霉素、西索米星、阿米卡星、庆大霉素和奈替米星（SCH 20569）的体外活性与从住院儿童中培养出的26株对庆大霉素耐药的铜绿假单胞菌分离株进行了比较。以重量计，妥布霉素的活性最强，其次是西索米星、庆大霉素、阿米卡星和奈替米星。所有分离株对奈替米星和庆大霉素可达到的浓度均耐药，但23%的分离株被妥布霉素可达到的浓度抑制，8%被阿米卡星抑制，4%被西索米星抑制。羧苄西林/妥布霉素、羧苄西林/西索米星和羧苄西林/阿米卡星组合对92%的菌株具有协同作用；未发现拮抗作用。这些体外研究结果表明，在进行药敏试验之前，妥布霉素、西索米星或阿米卡星与羧苄西林联合使用将是治疗耐庆大霉素铜绿假单胞菌感染最安全的初始治疗方案。
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Activity of newer aminoglycosides and carbenicillin, alone and in combination, against gentamicin-resistant Pseudomonas aeruginosa.新型氨基糖苷类抗生素和羧苄青霉素单独及联合使用时对庆大霉素耐药铜绿假单胞菌的活性。
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