Racine Jennifer, Aaron Roy K
MBA candidate at the University of Rhode Island, and Academic Coordinator and Research Associate, Department of Orthopaedics, The Warren Alpert Medical School of Brown University.
Professor of Orthopedic Surgery, Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Director of the Orthopedic Cell Biology Laboratory and the Orthopedic Program in Clinical/Translational Research.
R I Med J (2013). 2014 Nov 3;97(11):25-8.
Post-traumatic osteoarthritis (PTOA) occurs as a consequence of joint trauma or occupations or sports that subject joints to excessive loading stresses. Ligament injuries to the knee, particularly tears of the anterior cruciate ligament (ACL), often result in PTOA. Approximately half of the individuals with an ACL injury develop PTOA regardless of the reconstruction of the torn ligament. This observation has raised the possibility that other injuries occur to the knee in association with ACL tears that may involve ligamentous capsular structures, articular cartilage, or subchondral bone. Many ACL injuries occur in noncontact sports and are the result of biomechanical abnormalities. Female athletes are more likely than their male counterparts to suffer ACL injuries. This review outlines the epidemiology of ACL tears, its pathology in cartilage and bone, some of the demographic, biomechanical, and neuromuscular factors involved in ACL tears, and PTOA and important information gained from preclinical injury models.
创伤后骨关节炎(PTOA)是由关节创伤或使关节承受过度负荷应力的职业或运动引起的。膝关节韧带损伤,尤其是前交叉韧带(ACL)撕裂,常导致PTOA。约一半ACL损伤患者无论撕裂韧带是否重建都会发生PTOA。这一观察结果引发了一种可能性,即与ACL撕裂相关的膝关节还会发生其他损伤,可能涉及韧带关节囊结构、关节软骨或软骨下骨。许多ACL损伤发生在非接触性运动中,是生物力学异常的结果。女性运动员比男性运动员更易遭受ACL损伤。本综述概述了ACL撕裂的流行病学、其在软骨和骨中的病理学、ACL撕裂涉及的一些人口统计学、生物力学和神经肌肉因素,以及PTOA和从临床前损伤模型中获得的重要信息。