Lim Yi Chung, Cooling Michael T, Long David S
Auckland Bioengineering Institute, University of Auckland, 70 Symonds St, Auckland, 1010, New Zealand.
Biomech Model Mechanobiol. 2015 Jun;14(3):665-78. doi: 10.1007/s10237-014-0629-x. Epub 2014 Nov 4.
In endothelial cells (ECs), the mechanotransduction of fluid shear stress is partially dependent on the transmission of force from the fluid into the cell (mechanotransmission). The role of the primary cilium in EC mechanotransmission is not yet known. To motivate a framework towards quantifying cilia contribution to EC mechanotransmission, we have reviewed mechanical models of both (1) the primary cilium (three-dimensional and lower-dimensional) and (2) whole ECs (finite element, non-finite element, and tensegrity). Both the primary cilia and whole EC models typically incorporate fluid-induced wall shear stress and spatial geometry based on experimentally acquired images of cells. This paper presents future modelling directions as well as the major goals towards integrating primary cilium models into a multi-component EC mechanical model. Finally, we outline how an integrated cilium-EC model can be used to better understand mechanotransduction in the endothelium.
在内皮细胞（ECs）中，流体剪切应力的机械转导部分依赖于力从流体传递到细胞内（机械传递）。初级纤毛在EC机械传递中的作用尚不清楚。为了推动一个量化纤毛对EC机械传递贡献的框架，我们回顾了以下两种机械模型：（1）初级纤毛（三维和低维）和（2）完整的ECs（有限元、非有限元和平行张力结构）。初级纤毛模型和完整EC模型通常都基于通过实验获取的细胞图像纳入了流体诱导的壁面剪切应力和空间几何结构。本文提出了未来的建模方向以及将初级纤毛模型整合到多组分EC机械模型中的主要目标。最后，我们概述了如何使用整合的纤毛-EC模型来更好地理解内皮中的机械转导。
