Paine Nicola J, Bosch Jos A, Ring Christopher, Drayson Mark T, Veldhuijzen van Zanten Jet J C S
School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA.
Psychophysiology. 2015 Mar;52(3):333-41. doi: 10.1111/psyp.12360. Epub 2014 Nov 4.
Elevated inflammatory levels are linked to poorer cognition, but experimental confirmation is lacking. This report examined associations between cognitive performance and inflammation induced by exercise and vaccination. Thirty-six (exercise N = 18, vaccination N = 18) healthy males completed a paced auditory serial addition test (PASAT), which is a multifaceted measure of cognitive function. The task was completed in placebo and elevated inflammation states. Improvements in PASAT performance were related to inflammation. In the exercise study, IL-6 during the first PASAT negatively correlated with PASAT improvement (p = .022). In the vaccination study, increases in C-reactive protein between PASATs correlated with reduced PASAT improvement (p < .001). Inflammation was linked to reduced improvements in cognitive performance. Further research should identify the specific cognitive functions affects and the underlying mechanisms.
炎症水平升高与较差的认知能力有关，但缺乏实验证实。本报告研究了运动和疫苗接种诱导的炎症与认知表现之间的关联。三十六名（运动组N = 18，疫苗接种组N = 18）健康男性完成了一项听觉序列加法测验（PASAT），这是一种对认知功能的多方面测量。该任务在安慰剂和炎症水平升高状态下完成。PASAT表现的改善与炎症有关。在运动研究中，第一次PASAT期间的白细胞介素-6与PASAT改善呈负相关（p = 0.022）。在疫苗接种研究中，两次PASAT之间C反应蛋白的增加与PASAT改善减少相关（p < 0.001）。炎症与认知表现的改善减少有关。进一步的研究应确定受影响的具体认知功能及其潜在机制。
