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通过同种异体抗原刺激实现自然杀伤细胞的抗原特异性扩增和分化。

Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.

作者信息

Nabekura Tsukasa, Lanier Lewis L

机构信息

Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143 Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143 Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan.

Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143 Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143

出版信息

J Exp Med. 2014 Nov 17;211(12):2455-65. doi: 10.1084/jem.20140798. Epub 2014 Nov 3.

DOI:10.1084/jem.20140798
PMID:25366966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4235640/
Abstract

Natural killer (NK) cells provide important host defense against microbial pathogens and can generate a population of long-lived memory NK cells after infection or immunization. Here, we addressed whether NK cells can expand and differentiate after alloantigen stimulation, which may be important in hematopoietic stem cell and solid tissue transplantation. A subset of NK cell in C57BL/6 mice expresses the activating Ly49D receptor that is specific for H-2D(d). These Ly49D(+) NK cells can preferentially expand and differentiate when challenged with allogeneic H-2D(d) cells in the context of an inflammatory environment. H-2D(d) is also recognized by the inhibitory Ly49A receptor, which, when coexpressed on Ly49D(+) NK cells, suppresses the expansion of Ly49D(+) NK cells. Specificity of the secondary response of alloantigen-primed NK cells was defined by the expression of activating Ly49 receptors and regulated by the inhibitory receptors for MHC class I. Thus, the summation of signals through a repertoire of Ly49 receptors controls the adaptive immune features of NK cells responding to allogeneic cells.

摘要

自然杀伤（NK）细胞为宿主抵御微生物病原体提供重要防御，并且在感染或免疫后可产生一群长寿的记忆性NK细胞。在此，我们探讨了NK细胞在同种异体抗原刺激后是否能够扩增和分化，这在造血干细胞和实体组织移植中可能具有重要意义。C57BL/6小鼠中的一部分NK细胞表达对H-2D(d)具有特异性的活化性Ly49D受体。当在炎症环境中受到同种异体H-2D(d)细胞攻击时，这些Ly49D(+) NK细胞能够优先扩增和分化。H-2D(d)也被抑制性Ly49A受体识别，当Ly49D(+) NK细胞共表达该受体时，会抑制Ly49D(+) NK细胞的扩增。同种异体抗原致敏的NK细胞二次反应的特异性由活化性Ly49受体的表达所界定，并受MHC I类抑制性受体的调控。因此，通过一系列Ly49受体的信号总和控制着NK细胞对同种异体细胞反应的适应性免疫特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/ec5ef519eab6/JEM_20140798_Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/da3a4750ca6a/JEM_20140798_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/6d9fe0b9c5ff/JEM_20140798_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/780d1c4fa595/JEM_20140798_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/eac4d893f879/JEM_20140798_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/cbeb16a5e9c5/JEM_20140798_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/ec5ef519eab6/JEM_20140798_Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/da3a4750ca6a/JEM_20140798_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/6d9fe0b9c5ff/JEM_20140798_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/780d1c4fa595/JEM_20140798_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/eac4d893f879/JEM_20140798_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/cbeb16a5e9c5/JEM_20140798_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e455/4235640/ec5ef519eab6/JEM_20140798_Fig6.jpg

相似文献

[1]
Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.

J Exp Med. 2014-11-17

[2]
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[3]
Ly49C Impairs NK Cell Memory in Mouse Cytomegalovirus Infection.

J Immunol. 2016-7-1

[4]
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J Exp Med. 2011-4-25

[5]
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Am J Reprod Immunol. 2000-7

[6]
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[7]
MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells.

J Immunol. 2001-6-1

[8]
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[9]
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.

Eur J Immunol. 2002-3

[10]
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J Immunol. 2003-9-15

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Immune Netw. 2024-6-27

[3]
Tissue-resident memory NK cells: Homing in on local effectors and regulators.

Immunol Rev. 2024-5

[4]
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[5]
Memory-like NK Cells Are a Critical Component of Vaccine-Induced Immunity to Trypanosoma cruzi Infection.

J Immunol. 2024-2-15

[6]
Themis2 regulates natural killer cell memory function and formation.

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[7]
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Signal Transduct Target Ther. 2023-3-11

[8]
Epigenetic regulation of natural killer cell memory.

Immunol Rev. 2022-1

[9]
Commentary: PIRs Mediate Innate Myeloid Cell Memory to Nonself MHC Molecules.

Front Immunol. 2021-10-14

[10]
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本文引用的文献

[1]
The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.

Immunogenetics. 2014-8

[2]
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.

Immunity. 2014-1-16

[3]
Natural killer cells: walking three paths down memory lane.

Trends Immunol. 2013-3-14

[4]
Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen.

J Immunol. 2012-10-17

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HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.

N Engl J Med. 2012-8-30

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Proinflammatory cytokine signaling required for the generation of natural killer cell memory.

J Exp Med. 2012-4-9

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Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.

Blood. 2011-12-16

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Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.

Proc Natl Acad Sci U S A. 2011-8-8

[9]
Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients.

Blood. 2011-5-3

[10]
Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

Nat Immunol. 2010-10-24

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