瞬时受体电位阳离子通道亚家族M成员7（TRPM7）在癌症中的作用：一种潜在的预后因素。
TRPM7 involvement in cancer: a potential prognostic factor.
作者信息
Dhennin-Duthille Isabelle, Gautier Mathieu, Korichneva Irina, Ouadid-Ahidouch Halima
机构信息
University of Picardie Jules Verne, UFR Sciences, Laboratory of Cell and Molecular Physiology, EA 4667, SFR CAP-SANTE (FED 4231), Amiens, France.
出版信息
Magnes Res. 2014 Jul-Sep;27(3):103-12. doi: 10.1684/mrh.2014.0367.
Calcium (Ca(2+)) and magnesium (Mg(2+)) are important metal elements that regulate a variety of cellular processes such as proliferation, migration, and apoptosis, in cancer cells. Among the ionic channels mediating intracellular entry, the transient receptor potential melastatin type 7 (TRPM7) channel is of particular interest, it being a non-selective, cationic channel mediating both Ca(2+) and Mg(2+) influx. TRPM7 is highly expressed in a number of human cancer tissues and cell lines. In this review, we summarise current knowledge on the physiological role of the dual function TRPM7 chanzyme, the potential application of TRPM7 as a diagnostic and prognostic marker of cancer progression with respect to clinical and pathological characteristics, and the molecular mechanisms implicated in cancerogenesis that specifically involve Ca(2+) and Mg(2+) influx through TRPM7 or kinase activity and interaction with cytoskeletal proteins.
钙（Ca(2+)）和镁（Mg(2+)）是重要的金属元素，可调节癌细胞中的多种细胞过程，如增殖、迁移和凋亡。在介导细胞内进入的离子通道中，瞬时受体电位褪黑素7型（TRPM7）通道特别受关注，它是一种非选择性阳离子通道，介导Ca(2+)和Mg(2+)内流。TRPM7在许多人类癌症组织和细胞系中高度表达。在本综述中，我们总结了关于双功能TRPM7酶生理作用的当前知识、TRPM7作为癌症进展的诊断和预后标志物在临床和病理特征方面的潜在应用，以及癌症发生过程中涉及的分子机制，这些机制具体涉及通过TRPM7的Ca(2+)和Mg(2+)内流或激酶活性以及与细胞骨架蛋白的相互作用。
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