Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Centre, University of Glasgow, Glasgow G12 8TA, UK.
Int J Mol Sci. 2019 Apr 16;20(8):1877. doi: 10.3390/ijms20081877.
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the divalent cations Mg, Ca, and Zn, and an α-kinase that phosphorylates downstream substrates. TRPM7 and its homologue TRPM6 have been implicated in a variety of cellular functions and is critically associated with intracellular signaling, including receptor tyrosine kinase (RTK)-mediated pathways. Emerging evidence indicates that growth factors, such as EGF and VEGF, signal through their RTKs, which regulate activity of TRPM6 and TRPM7. TRPM6 is primarily an epithelial-associated channel, while TRPM7 is more ubiquitous. In this review we focus on TRPM7 and its association with growth factors, RTKs, and downstream kinase signaling. We also highlight how interplay between TRPM7, Mg and signaling kinases influences cell function in physiological and pathological conditions, such as cancer and preeclampsia.
瞬时受体电位 melastatin 亚家族成员 7（TRPM7）是一种广泛表达的通道酶，具有对二价阳离子 Mg、Ca 和 Zn 通透的离子通道，以及磷酸化下游底物的 α-激酶。TRPM7 及其同源物 TRPM6 参与多种细胞功能，与细胞内信号转导密切相关，包括受体酪氨酸激酶（RTK）介导的途径。新出现的证据表明，生长因子，如 EGF 和 VEGF，通过其 RTK 信号转导，调节 TRPM6 和 TRPM7 的活性。TRPM6 主要是一种上皮相关通道，而 TRPM7 则更为普遍。在这篇综述中，我们重点介绍 TRPM7 及其与生长因子、RTK 和下游激酶信号转导的关系。我们还强调了 TRPM7、Mg 和信号转导激酶之间的相互作用如何影响生理和病理条件下（如癌症和子痫前期）的细胞功能。
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