EGF promotes mammalian cell growth by suppressing cellular senescence.
作者信息
Alexander Peter B, Yuan Lifeng, Yang Pengyuan, Sun Tao, Chen Rui, Xiang Handan, Chen Jiekai, Wu Haoyu, Radiloff Daniel R, Wang Xiao-Fan
机构信息
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
出版信息
Cell Res. 2015 Jan;25(1):135-8. doi: 10.1038/cr.2014.141. Epub 2014 Nov 4.
Abstract
摘要
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Programmed cell senescence during mammalian embryonic development.哺乳动物胚胎发育过程中的程序性细胞衰老。
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.清除 p16Ink4a 阳性衰老细胞可延缓与衰老相关的疾病。
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.衰老相关分泌表型揭示了致癌RAS和p53肿瘤抑制因子的细胞非自主功能。
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