Gil Luiz F, Suzuki Marcelo, Janal Malvin N, Tovar Nick, Marin Charles, Granato Rodrigo, Bonfante Estevam A, Jimbo Ryo, Gil Jose N, Coelho Paulo G
Department of Dentistry, Division of Oral and Maxillofacial Surgery, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Department of Prosthodontics and Operative Dentistry, Tufts University School of Dental Medicine, Boston, Massachusetts.
J Biomed Mater Res B Appl Biomater. 2015 Aug;103(6):1328-32. doi: 10.1002/jbm.b.33311. Epub 2014 Nov 4.
Although preclinical and sparse human histology retrieval studies have shown that the interface between implant and bone is constantly remodeling, no human retrieval database has been developed to determine the effect of functional loading time and other clinical/implant design variables on osseointegration. The present study tested the hypothesis that bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) increase over functional loading time around dental implants. Due to prosthetic retreatment reasons, 93 human implant retrievals from the same manufacturer (Bicon LLC, Boston, MA, USA) were obtained over a period of approximately 15 years. The retrieved implants were under functional loading from 120 days to ∼18 years and were histomorphologic/metrically evaluated. BIC/BAFO were assessed as a function of multiple independent variables: implant surface type, diameter, length, jaw (maxilla/mandible), region (anterior/posterior), and time of functional loading. The results showed that both BIC and BAFO increased over time independently of implant design/clinical variables, supporting the postulated hypothesis.
尽管临床前和少量人体组织学检索研究表明，植入物与骨之间的界面在不断重塑，但尚未建立人类检索数据库来确定功能加载时间以及其他临床/植入物设计变量对骨整合的影响。本研究检验了以下假设：在牙种植体周围，骨与种植体接触（BIC）和骨面积分数占有率（BAFO）会随着功能加载时间的增加而增加。由于修复后治疗的原因，在大约15年的时间里，从同一制造商（美国马萨诸塞州波士顿的Bicon LLC）获取了93例人体植入物样本。这些取出的种植体的功能加载时间为120天至约18年，并进行了组织形态学/测量学评估。BIC/BAFO根据多个独立变量进行评估：种植体表面类型、直径、长度、颌骨（上颌/下颌）、区域（前部/后部）以及功能加载时间。结果表明，BIC和BAFO均随时间增加，且与种植体设计/临床变量无关，支持了所提出的假设。
