Masood Yaghma, Kqueen Cheah Yoke, Rajadurai Pathmanathan
Faculty of Dentistry, Centre of Oral and Maxillofacial Diagnostics and Medicine Studies, Universiti Teknologi MARA, Level 19, Tower 2, Shah Alam, 40450, Malaysia.
Expert Rev Anticancer Ther. 2015 Feb;15(2):183-97. doi: 10.1586/14737140.2015.978294. Epub 2014 Nov 4.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Evidence suggests that miRNAs play an important role in progression, recurrence, metastasis and postoperative survival of HNSCC. Studies have investigated the utility of miRNAs as diagnostic/prognostic tools and as potential therapeutic targets and biomarkers that may improve the management and outcomes of HNSCC. The aim of this article is to review the current literature on aberrant expression profiles of miRNAs in biopsy samples of HNSCC and their role in cancer development, metastasis, prognosis and survival of these patients. This review gives an overview that miRNAs deregulation play major role in the development of HNSCC. They offer the potential to be used as biomarkers or novel therapeutic targets. Future research is required to test their use in both of these fields.
头颈部鳞状细胞癌（HNSCC）是全球第六大常见恶性肿瘤。有证据表明，微小RNA（miRNA）在HNSCC的进展、复发、转移及术后生存中发挥着重要作用。研究已探讨了miRNA作为诊断/预后工具以及作为潜在治疗靶点和生物标志物的效用，这些可能会改善HNSCC的管理和治疗结果。本文的目的是综述目前关于HNSCC活检样本中miRNA异常表达谱及其在这些患者癌症发生、转移、预后和生存中作用的文献。本综述概述了miRNA失调在HNSCC发生中起主要作用。它们有潜力用作生物标志物或新型治疗靶点。未来需要开展研究以测试其在这两个领域的应用。
