Sari Sebahattin, Sari Erkan, Akgun Veysel, Ozcan Emrah, Ince Selami, Saldir Mehmet, Babacan Oguzhan, Acikel Cengizhan, Basbozkurt Gokalp, Ozenc Salim, Yesilkaya Sirzat, Kilic Cenk, Kara Kemal, Vurucu Sebahattin, Kocaoglu Murat, Yesilkaya Ediz
J Pediatr Endocrinol Metab. 2014 Nov;27(11-12):1071-6. doi: 10.1515/jpem-2014-0054.
The aim of this study is to provide normative data about pituitary diameters in a pediatric population. Pituitary imaging is important for the evaluation of the hypothalamo-pituitary axis defect. However, data about normal pituitary gland diameters and stalk are limited, especially in children. Structure and the measurements of pituitary gland and pituitary stalk may change due to infection, inflammation, or neoplasia.
Among 14,854 cranial/pituitary gland magnetic resonance imaging scans performed from 2011 to 2013, 2755 images of Turkish children aged between 0 and 18 were acquired. After exclusions, 517 images were left. Four radiologists were educated by an experienced pediatric radiologist for the measurement and assessment of the pituitary gland and pituitary stalk. Twenty cases were measured by all radiologists for a pilot study and there was no interobserver variability.
There were 10-22 children in each age group. The maximum median height of the pituitary gland was 8.48±1.08 and 6.19±0.88 mm for girls and boys, respectively. Volumes were also correlated with gender similar to height. Minimum median height was 3.91±0.75 mm for girls and 3.81±0.68 mm for boys. The maximum and minimum pituitary stalk basilar artery ratios for girls were 0.73±0.12 and 0.59±0.10 mm. The ratios for boys were 0.70±0.12 and 0.56±0.11 mm.
Our study demonstrated the pituitary gland and stalk size data of children in various age groups from newborn to adolescent. It is thought that these data can be applied in clinical practice. Future prospective follow-up studies with larger samples, which correlate the structural findings with the clinical and laboratory results are awaited.
本研究旨在提供儿科人群垂体直径的规范数据。垂体成像对于评估下丘脑 - 垂体轴缺陷很重要。然而，关于正常垂体腺直径和垂体柄的数据有限，尤其是在儿童中。垂体腺和垂体柄的结构及测量值可能因感染、炎症或肿瘤形成而改变。
在2011年至2013年进行的14854次头颅/垂体腺磁共振成像扫描中，获取了2755例0至18岁土耳其儿童的图像。排除后，剩下517张图像。由一位经验丰富的儿科放射科医生对四位放射科医生进行垂体腺和垂体柄测量及评估的培训。所有放射科医生对20例进行了测量作为预试验研究，观察者间无差异。
每个年龄组有10 - 22名儿童。女孩和男孩垂体腺的最大中位数高度分别为8.48±1.08毫米和6.19±0.88毫米。体积也与性别相关，与高度类似。女孩的最小中位数高度为3.91±0.75毫米，男孩为3.81±0.68毫米。女孩垂体柄基底动脉的最大和最小比例分别为0.73±0.12和0.59±0.10毫米。男孩的比例为0.70±0.12和0.56±0.11毫米。
我们的研究展示了从新生儿到青少年各年龄组儿童的垂体腺和垂体柄大小数据。认为这些数据可应用于临床实践。期待未来有更大样本的前瞻性随访研究，将结构发现与临床和实验室结果相关联。
