Mahaley M S, Hipp S W, Dropcho E J, Bertsch L, Cush S, Tirey T, Gillespie G Y
Division of Neurological Surgery, University of Alabama, Birmingham.
J Neurosurg. 1989 Mar;70(3):371-8. doi: 10.3171/jns.1989.70.3.0371.
Forty patients with recurrent gliomas were treated with monthly intra-arterial infusions of cisplatin. Of the 35 evaluable patients, 12 (34%) responded with computerized tomography (CT) evidence of a decrease in tumor size; in 14 (40%) the tumor stabilized on CT scans, and in nine (26%) the disease progressed. The median survival period was 35.0 weeks for the responders and 27.5 weeks for all 35 patients. The primary toxicities were renal (reversible alterations in creatinine clearance), otological (severe hearing loss in one patient), and likely neurotoxicity in one patient who had received bilateral infusions following contralateral tumor progression. The authors are now using this form of regional chemotherapy sequentially before and following radiotherapy in newly diagnosed cases.
40例复发性神经胶质瘤患者接受了每月一次的顺铂动脉内灌注治疗。在35例可评估的患者中，12例（34%）有计算机断层扫描（CT）证据显示肿瘤大小减小，即有反应；14例（40%）肿瘤在CT扫描中稳定，9例（26%）病情进展。有反应者的中位生存期为35.0周，35例患者的总体中位生存期为27.5周。主要毒性反应包括肾脏毒性（肌酐清除率的可逆性改变）、耳毒性（1例患者出现严重听力丧失），以及1例在对侧肿瘤进展后接受双侧灌注的患者可能出现的神经毒性。作者目前正在新诊断病例中，在放疗前后依次使用这种区域化疗形式。
