Brambilla Bas M, Boccardo M
Department of Neurosurgery, S. Corona Hospital, Pietra Ligure, Italy.
J Neurosurg Sci. 1993 Jun;37(2):83-6.
Twenty-five patients with malignant astrocytomas (grade III and IV) were treated with intraarterial infusions of cisplatin at 4/8 weeks intervals. Of the 23 evaluable patients, none had a complete response, 1 (4.3%) had a probable response (unequivocal improvement in the neurological examination and CT evidence of a decrease in tumor size), 15 (65.2%) had stable disease, and 7 (30.5%) had a progression (unequivocal worsening of both the neurological examination and the CT scan). Twenty-one of the 25 patients exhibited some degree of toxicity; the only two serious complications observed were neurological and retinal.
25例恶性星形细胞瘤（Ⅲ级和Ⅳ级）患者接受了顺铂动脉内输注治疗，间隔时间为4/8周。在23例可评估的患者中，无完全缓解者，1例（4.3%）可能缓解（神经学检查有明确改善且CT显示肿瘤大小减小），15例（65.2%）病情稳定，7例（30.5%）病情进展（神经学检查和CT扫描均有明确恶化）。25例患者中有21例出现了一定程度的毒性反应；观察到的仅有的两个严重并发症是神经和视网膜方面的。
