Molenaar W M, DeJong B, Buist J, Idenburg V J, Seruca R, Vos A M, Hoekstra H J
Department of Pathology, University of Groningen, The Netherlands.
Lab Invest. 1989 Feb;60(2):266-74.
Seventeen soft tissue sarcomas were karyotyped and the chromosomal findings were compared with those in the literature. Some cases were easily classified (immuno)histologically, whereas others defied classification. In four cases with unequivocal histology, a "characteristic" chromosomal abnormality was found. In one case a diagnosis that was doubtful on histologic grounds was supported by the chromosomal findings, whereas in three other cases, the chromosomal pattern led to reconsideration of the histologic diagnosis. The remaining cases either showed chromosomal abnormalities with hitherto undescribed breakpoints or breakpoints described in tumors with different histology. The results extend the knowledge of chromosomal abnormalities in soft tissue sarcomas. Most importantly, the present approach demonstrates that close collaboration between the surgical pathologist and the cytogeneticist may improve the classification of soft tissue sarcomas.
对17例软组织肉瘤进行了核型分析，并将染色体检查结果与文献中的结果进行了比较。有些病例在（免疫）组织学上很容易分类，而其他病例则难以分类。在4例组织学明确的病例中，发现了“特征性”染色体异常。在1例组织学诊断存疑的病例中，染色体检查结果支持了该诊断，而在其他3例病例中，染色体模式导致对组织学诊断进行重新考虑。其余病例要么显示出具有迄今未描述的断点的染色体异常，要么显示出在不同组织学肿瘤中描述的断点。这些结果扩展了对软组织肉瘤染色体异常的认识。最重要的是，目前的方法表明，外科病理学家和细胞遗传学家之间的密切合作可能会改善软组织肉瘤的分类。
