Robertson Deirdre A, Savva George M, Coen Robert F, Kenny Rose-Anne
The Irish Longitudinal Study on Ageing (TILDA), Department of Medical Gerontology, Trinity College, Dublin, Ireland.
J Am Geriatr Soc. 2014 Nov;62(11):2118-24. doi: 10.1111/jgs.13111. Epub 2014 Nov 4.
To explore the relationship between cognitive function and frailty.
A cross-sectional study using data from Wave 1 of The Irish Longitudinal Study on Ageing, a population representative study of adults aged 50 and older in the Republic of Ireland.
Community-dwelling adults completed a home- or health center-based nurse-led assessment.
Individuals aged 50 and older without a history of stroke, Parkinson's disease, or severe cognitive impairment (Mini-Mental State Examination (MMSE) score <18) and not taking antidepressants (N = 4,649).
A cognitive battery including MMSE, Montreal Cognitive Assessment, Color Trails Test, Cambridge Mental Disorders of the Elderly Examination memory and executive function subtests, 10-word recall, Sustained Attention to Response Task, and choice reaction time was used to generate composite scores of cognitive domains. Frailty was assessed according to weakness, slowness, exhaustion, low physical activity, and weight loss.
After full adjustment, cognitive function across all domains except self-rated memory and processing speed was significantly worse in prefrail and frail participants (P < .05) than in those who were robust. Weakness and walking speed were most consistently linked to poorer cognition, whereas low activity and weight loss were not independently associated with any cognitive domain. Exhaustion was associated with global cognition (B = -0.18 ± 0.06), with some evidence of links to objectively measured and self-rated memory.
Cognitive function is worse across multiple cognitive domains in prefrail and frail individuals aged 50 and older than in those who are robust, although the absolute differences are small after adjusting for confounding factors.
探讨认知功能与衰弱之间的关系。
一项横断面研究，使用来自爱尔兰老龄化纵向研究第一波的数据，该研究是爱尔兰共和国50岁及以上成年人的一项具有人口代表性的研究。
社区居住的成年人完成了一项由护士主导的基于家庭或健康中心的评估。
年龄在50岁及以上、无中风、帕金森病或严重认知障碍病史（简易精神状态检查表（MMSE）评分<18）且未服用抗抑郁药的个体（N = 4649）。
使用包括MMSE、蒙特利尔认知评估、色线测试、剑桥老年精神障碍检查记忆和执行功能子测试、10词回忆、持续注意力反应任务和选择反应时间的认知测试组合来生成认知领域的综合得分。根据虚弱、行动迟缓、疲惫、低体力活动和体重减轻来评估衰弱情况。
在进行全面调整后，除自我评定的记忆和处理速度外，所有认知领域的认知功能在衰弱前期和衰弱参与者中（P < 0.05）均显著差于健康参与者。虚弱和步行速度与较差的认知最密切相关，而低活动量和体重减轻与任何认知领域均无独立关联。疲惫与整体认知相关（B = −0.18 ± 0.06），有一些证据表明其与客观测量和自我评定的记忆存在关联。
50岁及以上的衰弱前期和衰弱个体在多个认知领域的认知功能比健康个体差，尽管在调整混杂因素后绝对差异较小。
