Mierzecki Artur, Makarewicz-Wujec Magdalena, Kłoda Karolina, Kozłowska-Wojciechowska Małgorzata, Pieńkowski Paweł, Naruszewicz Marek
Independent Laboratory of Family Physician Education, Pomeranian Medical University in Szczecin.
Kardiol Pol. 2015;73(4):280-6. doi: 10.5603/KP.a2014.0209. Epub 2014 Nov 5.
The human body requires folic acid (FA) to produce blood cells, secure cell division, and growth. Moreover, this vitamin is important in the prevention of cardiovascular disease (CVD). Because the results of studies on the use of FA in the prevention of CVD are ambiguous, it seems necessary to conduct further research, which will explain in which cases supplementation is effective.
To assess the impact of FA supplementation on the coagulation, inflammatory, lipid parameters, and kidney function in subjects with atherosclerosis risk factors, depending on the content of FA in their diet.
The study enrolled 97 young adult Caucasian individuals (34 males and 63 females) with atherosclerosis risk factors. This population was divided into two groups: A--with low content of FA in the diet (< 40% of reference daily intake) and B--with moderate content of FA in the diet (40-90% of reference daily intake). The participants were asked to take FA in the low-dose of 0.4 mg/24 h for 3 months.
Low-dose FA supplementation resulted in elevation of FA concentrations (79% vs. 75.1%) in the studied groups and, concomitantly, a decrease in homocysteine concentrations (21% vs. 20.3%). Mean level of creatinine decreased after FA supplementation in both groups (0.93 ± 1.1 vs. 0.72 ± 0.15 mg/dL and 0.83 ± 0.16 vs. 0.77 ± 0.15 mg/dL). These differences were statistically significant (p < 0.0001). The difference in mean estimated glomerular filtration rate values before and after FA supplementation was statistically significant in group A (p = 0.002) and on the border of statistical significance in group B (p = 0.06).
FA supplementation has no influence on the coagulation, inflammatory and lipid parameters in subjects with atherosclerosis risk factors depending on the content of FA in their diet. However FA supplementation may have a beneficial effect on kidney function in subjects with low content of FA in the diet.
人体需要叶酸（FA）来生成血细胞、确保细胞分裂和生长。此外，这种维生素在预防心血管疾病（CVD）方面也很重要。由于关于使用叶酸预防心血管疾病的研究结果不明确，因此似乎有必要进行进一步研究，以解释在哪些情况下补充叶酸是有效的。
根据饮食中叶酸的含量，评估补充叶酸对有动脉粥样硬化风险因素的受试者的凝血、炎症、脂质参数和肾功能的影响。
该研究招募了97名有动脉粥样硬化风险因素的年轻成年白种人（34名男性和63名女性）。该人群被分为两组：A组——饮食中叶酸含量低（<参考每日摄入量的40%）和B组——饮食中叶酸含量中等（参考每日摄入量的40-90%）。参与者被要求连续3个月每天服用低剂量0.4毫克/24小时的叶酸。
低剂量补充叶酸导致研究组中叶酸浓度升高（79%对75.1%），同时同型半胱氨酸浓度降低（21%对20.3%）。两组补充叶酸后肌酐平均水平均下降（0.93±1.1对0.72±0.15毫克/分升和0.83±0.16对0.77±0.15毫克/分升）。这些差异具有统计学意义（p<0.0001）。补充叶酸前后平均估计肾小球滤过率值的差异在A组具有统计学意义（p=0.002），在B组接近统计学意义（p=0.06）。
根据饮食中叶酸的含量，补充叶酸对有动脉粥样硬化风险因素的受试者的凝血、炎症和脂质参数没有影响。然而，补充叶酸可能对饮食中叶酸含量低的受试者的肾功能有有益影响。
