冠醚可减轻阿尔茨海默病中β淀粉样蛋白的聚集。
Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
作者信息
Tian Yanli, Zhang Xueli, Li Yuyan, Shoup Timothy M, Teng Xin, Elmaleh David R, Moore Anna, Ran Chongzhao
机构信息
Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA.
出版信息
Chem Commun (Camb). 2014 Dec 25;50(99):15792-5. doi: 10.1039/c4cc06029f. Epub 2014 Nov 5.
Abstract
In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.
摘要
在本报告中，我们推断冠醚对β淀粉样蛋白（Aβ）的非共价修饰可抑制其聚集。我们证明，芘丁酸-冠醚共轭物（PiB-C）可在体外显著减少聚集。此外，双光子成像显示PiB-C可有效标记AD小鼠中的Aβ斑块和脑淀粉样血管病（CAA）。
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