Watt-Boolsen S, Ottesen G, Andersen J A, Bayer T, Jespersen N C, Keiding N, Mouridsen H T, Dombernowsky P, Blichert-Toft M
Danish Breast Cancer Cooperative Group (DBCG), Finsen Institute, Copenhagen, Denmark.
Eur J Surg Oncol. 1989 Feb;15(1):33-7.
The recurrence-free survival rates (RFS) after one-stage mastectomy and partial axillary dissection in 1242 low risk breast cancer patients with invasive ductal carcinoma with or without residual cancer tissue (RCT) in the wall of the biopsy cavity were compared. RFS was significantly lower in patients with RCT (RCT-positive) whether premenopausal (n = 416) or postmenopausal (n = 826). By applying the Cox multivariate analysis on RCT and various known prognostic criteria, the incidence rates for RCT-positive patients relative to RCT-negative patients were estimated. The relative risk by RCT-positivity was in the order of 1.45, indicating that RCT is an independent risk factor contributing an increased risk of recurrence of about 45%.
比较了1242例患有浸润性导管癌的低风险乳腺癌患者在一期乳房切除和部分腋窝清扫术后的无复发生存率（RFS），这些患者活检腔壁中有或无残留癌组织（RCT）。无论绝经前（n = 416）还是绝经后（n = 826），RCT阳性患者的RFS均显著较低。通过对RCT和各种已知预后标准进行Cox多变量分析，估计了RCT阳性患者相对于RCT阴性患者的发病率。RCT阳性的相对风险约为1.45，表明RCT是一个独立的风险因素，会使复发风险增加约45%。
