Shelton G H, McKim K D, Cooley P L, Dice P F, Russell R G, Grant C K
FeLV Referral Clinic, Pacific Northwest Research Foundation, Seattle, WA 98122.
J Am Vet Med Assoc. 1989 Jan 15;194(2):249-52.
Lymphoma was diagnosed in a 7-year-old domestic cat found to be infected with FeLV and feline immunodeficiency virus (FIV). The cat was affected by chronic disorders suggestive of immunosuppression, including gingivitis, periodontitis, keratitis, and abscesses. Despite treatment, peripheral keratitis of the left eye progressed, resulting in uveitis, chronic glaucoma, and eventual corneal rupture. Microscopic retinal and optic disk pathologic processes also were suspected. Abnormal jaw movements that were believed to be indicative of neurologic disease were observed. Approximately 17 months later, the cat developed generalized lymphadenopathy, hepatosplenomegaly, and bilateral renomegaly. Lymphoblastic lymphoma and glomerulonephritis were diagnosed histologically. Manganese- and magnesium-dependent reverse transcriptase activity were detected in supernatants from lymph node and spleen mononuclear cell cultures, suggesting T-lymphocyte infection with FeLV and FIV.
一只7岁的家猫被诊断出患有淋巴瘤，该猫同时感染了猫白血病病毒（FeLV）和猫免疫缺陷病毒（FIV）。这只猫患有提示免疫抑制的慢性疾病，包括牙龈炎、牙周炎、角膜炎和脓肿。尽管进行了治疗，但左眼的周边角膜炎仍在进展，导致葡萄膜炎、慢性青光眼，最终角膜破裂。还怀疑存在微观视网膜和视盘病理过程。观察到被认为提示神经疾病的异常下颌运动。大约17个月后，这只猫出现全身淋巴结病、肝脾肿大和双侧肾肿大。组织学诊断为淋巴细胞性淋巴瘤和肾小球肾炎。在淋巴结和脾脏单核细胞培养物的上清液中检测到锰和镁依赖性逆转录酶活性，提示T淋巴细胞感染了FeLV和FIV。
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