脐带血造血干细胞的特征。
Characteristics of hematopoietic stem cells of umbilical cord blood.
机构信息
Department of Medical Chemistry, Medical Univeristy of Lublin, Lublin, Poland.
出版信息
Cytotechnology. 2015 May;67(3):387-96. doi: 10.1007/s10616-014-9796-y. Epub 2014 Nov 6.
Abstract
Umbilical cord blood collected from the postpartum placenta and cord is a rich source of hematopoietic stem cells (HSCs) and is an alternative to bone marrow transplantation. In this review we wanted to describe the differences (in phenotype, cytokine production, quantity and quality of cells) between stem cells from umbilical cord blood, bone marrow and peripheral blood. HSCs present in cord blood are more primitive than their counterparts in bone marrow or peripheral blood, and have several advantages including high proliferation. With using proper cytokine combination, HSCs can be effectively developed into different cell lines. This process is used in medicine, especially in hematology.
摘要
从产后胎盘和脐带中采集的脐带血是造血干细胞（HSCs）的丰富来源，是骨髓移植的一种替代方法。在这篇综述中，我们想描述脐带血、骨髓和外周血中的干细胞之间的差异（表型、细胞因子产生、细胞数量和质量）。脐带血中的 HSCs 比骨髓或外周血中的 HSCs 更原始，并且具有多种优势，包括高增殖能力。通过使用适当的细胞因子组合，可以有效地将 HSCs 分化为不同的细胞系。这个过程在医学中特别是血液学中得到了广泛应用。
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