通过亚磷酸三烷基酯的三组分反应绿色合成磷酰基-2-氧代-2H-吡喃
Green synthesis of phosphoryl-2-oxo-2H-pyran via three component reaction of trialkyl phosphites.
作者信息
Hossaini Zinatossadat, Sheikholeslami-Farahani Fatemeh, Rostami-Charati Faramarz
机构信息
Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
出版信息
Comb Chem High Throughput Screen. 2014;17(9):804-7. doi: 10.2174/1386207317666141106155038.
Abstract
An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkyl acetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50°C and neutral conditions and provided good yields of products.
摘要
描述了一种在亚磷酸三烷基酯存在下，通过烷基溴与二烷基乙炔二羧酸酯的三组分反应，有效一锅合成二烷氧基磷酰基-2-氧代-2H-吡喃衍生物的方法。该反应在无溶剂条件下于50℃和中性条件下进行，产物收率良好。
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