鼻咽癌非流行地区淋巴瘤中爱泼斯坦-巴尔病毒（EBV）BCRF1的序列变异
Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma.
作者信息
Han Lu, Sun Lingling, Zhao Zhenzhen, Chao Yan, Sun Zhifu, Li Hui, Luo Bing
机构信息
Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao, 266021, China.
出版信息
Arch Virol. 2015 Feb;160(2):441-5. doi: 10.1007/s00705-014-2279-9. Epub 2014 Nov 6.
To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin's lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.
为了表征爱泼斯坦-巴尔病毒（EBV）癌基因在淋巴瘤中的序列变异及其潜在影响，在中国北方不同类型的EBV阳性淋巴瘤中对BamHI-C片段右向阅读框1（BCRF1）进行了测序，并将多态性与先前来自其他恶性肿瘤的变异数据进行了比较。EBV阳性淋巴瘤中BCRF1的主要亚型是B95-8原型，信号肽中的突变与霍奇金淋巴瘤的相关性更强。BCRF1在EBV阳性淋巴瘤中的高度保守性表明其在维持病毒的基本生物学活性和免疫抑制功能方面具有重要作用。
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