Van der Kloot W
Department of Physiology and Biophysics, SUNY, Stony Brook 11794.
J Neurosci Methods. 1989 Feb;27(1):81-9. doi: 10.1016/0165-0270(89)90054-x.
It has been proposed that at the neuromuscular junction quanta are made up of subunits, because regularly spaced peaks appear in some histograms of miniature end-plate potential (MEPP) amplitudes. Many sets of MEPP sizes fit lognormal probability distribution functions. I compared sets of MEPP amplitudes from the literature to lognormal distributions, using cumulative plots and a robust test for significance. Some data sets fit a single lognormal distribution, but most required two lognormal subpopulations. This bimodal model is a parsimonious alternative to the subunits hypothesis. I also used graphs in which cumulative MEPP sizes were plotted on the ordinate against probability on the abscissa. Model data sets, generated on the subunit assumptions, produced concave plots. End-plate potential sizes at low quantal outputs--in which we know there are subunits--show the same concave shape. Most of the tested data from the subunit literature produced convex curves.
有人提出，在神经肌肉接头处，量子是由亚基组成的，因为在一些微小终板电位（MEPP）振幅的直方图中出现了规则间隔的峰值。许多组MEPP大小符合对数正态概率分布函数。我使用累积图和一种稳健的显著性检验，将文献中的MEPP振幅组与对数正态分布进行了比较。一些数据集符合单一的对数正态分布，但大多数需要两个对数正态亚群。这种双峰模型是亚基假说的一种简洁替代方案。我还使用了这样的图表，其中累积MEPP大小绘制在纵坐标上，概率绘制在横坐标上。根据亚基假设生成的模型数据集产生凹形图。在低量子输出时的终板电位大小——我们知道其中存在亚基——呈现出相同的凹形。来自亚基文献的大多数测试数据产生凸曲线。
