Chang Ernest W, Gardecki Joseph, Pitman Martha, Wilsterman Eric J, Patel Ankit, Tearney Guillermo J, Iftimia Nicusor
Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.
Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom, Boston, Massachusetts 02114, United States.
J Biomed Opt. 2014;19(11):116005. doi: 10.1117/1.JBO.19.11.116005.
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.
我们展示了用于辅助细针穿刺活检的便携式临床前低相干干涉(LCI)仪器,其具有基于第二代LCI的活检探头和用于组织分化的改进评分算法。我们的仪器和算法在38只患有培养肿瘤块的小鼠身上进行了测试,结果表明肿瘤检测的特异性、敏感性和阳性预测值分别超过0.89、0.88和0.96。