Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
School of Surgery, University of Western Australia, Crawley, Western Australia, Australia.
Sci Adv. 2018 Dec 19;4(12):eaav4992. doi: 10.1126/sciadv.aav4992. eCollection 2018 Dec.
Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an "imaging needle" that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions.
颅内出血是脑活检相关的一种严重并发症。在将组织吸入针内并取出的过程中，可能会损伤临近活检针的血管。目前还没有术中技术可以可靠地识别有损伤风险的血管。为了解决这个问题，我们开发了一种“成像针”，可以实时显示附近的血管。这种成像针内含有一个微型光学相干断层扫描探头，可以区分血流和组织。在 11 名患者中，我们能够以 91.2%的灵敏度和 97.7%的特异性术中检测到直径>500μm 的血管。这是首次在活体人脑中报告使用光学相干断层扫描针探头。这些结果表明，成像针可能成为各种神经外科针干预的有价值的工具。
