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Tentative identification of benzo[a]pyrene metabolite-nucleoside complexes produced in vitro by mouse liver microsomes.

作者信息

Pelkonen O, Boobis A R, Yagi H, Jerina D M, Nebert D W

出版信息

Mol Pharmacol. 1978 Mar;14(2):306-22.

PMID:25376
Abstract
摘要

相似文献

1
Tentative identification of benzo[a]pyrene metabolite-nucleoside complexes produced in vitro by mouse liver microsomes.小鼠肝脏微粒体体外产生的苯并[a]芘代谢物-核苷复合物的初步鉴定。
Mol Pharmacol. 1978 Mar;14(2):306-22.
2
K-region and non-K-region metabolism of benzo(a)pyrene by rat liver microsomes.大鼠肝微粒体对苯并(a)芘的K区和非K区代谢
Cancer Res. 1973 Aug;33(8):1937-44.
3
Inhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones.苯并(a)芘醌对苯并(a)芘和苯并(a)芘7,8-二氢二醇代谢的抑制作用。
Cancer Res. 1979 Oct;39(10):4123-9.
4
In vitro metabolism of benzo(a)pyrene by human liver microsomes and lymphocytes.苯并(a)芘在人肝微粒体和淋巴细胞中的体外代谢
Cancer Res. 1975 Dec;35(12):3651-5.
5
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.3-甲基胆蒽诱导的大鼠肝微粒体将苯并[a]芘代谢为二氢二醇环氧化物的动力学决定因素。
Mol Pharmacol. 1982 Sep;22(2):451-8.
6
The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes.通过肝微粒体对苯并(a)芘酚形成的直接分光光度法观察。
Cancer Res. 1976 Dec;36(12):4439-43.
7
The benzo(alpha)pyrene deoxyribonucleoside products isolated from DNA after metabolism of benzo(alpha)pyrene by rat liver microsomes in the presence of DNA.在DNA存在的情况下，大鼠肝脏微粒体对苯并（α）芘进行代谢后，从DNA中分离出的苯并（α）芘脱氧核糖核苷产物。
Cancer Res. 1975 May;35(5):1263-9.
8
Kinetic analysis of the metabolism of benzo(a)pyrene to phenols, dihydrodiols, and quinones by high-pressure chromatography compared to analysis by aryl hydrocarbon hydroxylase assay, and the effect of enzyme induction.通过高压色谱法对苯并(a)芘代谢为酚类、二氢二醇和醌类的动力学分析与通过芳烃羟化酶测定法的分析比较，以及酶诱导的影响。
Cancer Res. 1975 Dec;35(12):3642-50.
9
Comparison of epoxide and free-radical mechanisms for activation of benzo[a]pyrene by Sprague-Dawley rat liver microsomes.用斯普拉格-道利大鼠肝微粒体对苯并[a]芘激活的环氧化物和自由基机制的比较。
J Natl Cancer Inst. 1980 Apr;64(4):771-4.
10
Unusual patterns of benzo[a]pyrene metabolites and DNA-benzo[a]pyrene adducts produced by human placental microsomes in vitro.人胎盘微粒体体外产生的苯并[a]芘代谢物和DNA-苯并[a]芘加合物的异常模式。
Chem Biol Interact. 1980 Jun;30(3):287-96. doi: 10.1016/0009-2797(80)90051-4.

引用本文的文献

1
Effects of induction and age-dependent enzyme expression on lung bioavailability, metabolism, and DNA binding of urban air particulate-absorbed benzo[a]pyrene, 2-nitrofluorene, and 3-amino-1,4-dimethyl-5H-pyridol-(4,3)-indole.诱导和年龄依赖性酶表达对城市空气颗粒物吸附的苯并[a]芘、2-硝基芴和3-氨基-1,4-二甲基-5H-吡啶并-(4,3)-吲哚的肺生物利用度、代谢及DNA结合的影响
Environ Health Perspect. 1994 Oct;102 Suppl 4(Suppl 4):147-56. doi: 10.1289/ehp.102-1566925.
2
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.膳食抗氧化剂对NAD(P)H:醌还原酶的诱导作用：在预防癌症发生和毒性方面的可能作用。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5216-20. doi: 10.1073/pnas.77.9.5216.
3
Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo.三氯乙烯在体外与DNA以及在体内与各种小鼠组织的RNA和DNA的相互作用。
Arch Toxicol. 1983 Nov;54(3):181-93. doi: 10.1007/BF01239202.
4
Covalent binding of BP-metabolites to DNA of cultured human hair follicle keratinocytes.BP代谢产物与培养的人毛囊角质形成细胞DNA的共价结合。
Arch Toxicol. 1985 Apr;57(1):6-12. doi: 10.1007/BF00286567.
5
Binding of benzo(a)pyrene metabolites to cellular DNA in perfused rat lungs.苯并(a)芘代谢产物与灌注大鼠肺细胞DNA的结合。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):303-7. doi: 10.1007/BF00498059.