Fan Quli, Cheng Kai, Yang Zhen, Zhang Ruiping, Yang Min, Hu Xiang, Ma Xiaowei, Bu Lihong, Lu Xiaomei, Xiong Xiaoxing, Huang Wei, Zhao Heng, Cheng Zhen
Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing, 210046, China; Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, California, 94305-5484, USA.
Adv Mater. 2015 Feb 4;27(5):843-7. doi: 10.1002/adma.201402972. Epub 2014 Nov 6.
In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect.
为了促进光声成像的临床前和临床应用，迫切需要新型光声造影剂用于疾病的分子成像，特别是深部肿瘤成像。在此，报道了基于苝-3,4,9,10-四羧酸二酰亚胺的近红外吸收有机纳米颗粒作为一种有效的造影剂，用于对具有增强渗透和滞留效应的活体小鼠深部脑肿瘤进行光声成像。
