药物滥用的网关假说：发育、生物学和社会视角
The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectives.
作者信息
Kandel Denise, Kandel Eric
机构信息
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Mailman School of Public Health, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
出版信息
Acta Paediatr. 2015 Feb;104(2):130-7. doi: 10.1111/apa.12851. Epub 2014 Dec 2.
UNLABELLED
The Gateway Hypothesis describes how tobacco or alcohol use precedes marijuana and other illicit drug use. We review the epidemiological data, explore the underlying molecular mechanisms in mice and discuss the societal implications of the hypothesis, including the use of e-cigarettes by young people.
CONCLUSION
Our mouse model identifies biological processes underlying the hypothesis, showing that nicotine is a gateway drug that exerts a priming effect on cocaine through increased global acetylation in the striatum.
未标注
“通路假说”描述了烟草或酒精使用如何先于大麻及其他非法药物使用。我们回顾了流行病学数据，探究了小鼠体内潜在的分子机制，并讨论了该假说的社会影响，包括年轻人使用电子烟的情况。
结论
我们的小鼠模型确定了该假说背后的生物学过程，表明尼古丁是一种通路药物，通过增加纹状体中的整体乙酰化对可卡因产生启动效应。
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