通过Notch信号传导的上皮-基质相互作用对于肠道相关淋巴组织的完全成熟至关重要。
Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues.
作者信息
Obata Yuuki, Kimura Shunsuke, Nakato Gaku, Iizuka Keito, Miyagawa Yurika, Nakamura Yutaka, Furusawa Yukihiro, Sugiyama Machiko, Suzuki Keiichiro, Ebisawa Masashi, Fujimura Yumiko, Yoshida Hisahiro, Iwanaga Toshihiko, Hase Koji, Ohno Hiroshi
机构信息
Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Department of Immune Regulation, Graduate School of Medical and Pharmaceutical Sciences Chiba University, Chiba, Japan Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Laboratory of Histology and Cytology, Graduate School of Medicine Hokkaido University, Sapporo, Japan.
出版信息
EMBO Rep. 2014 Dec;15(12):1297-304. doi: 10.15252/embr.201438942. Epub 2014 Nov 5.
Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE.
肠道上皮细胞中的内在Notch信号传导限制分泌细胞分化。在肠道相关淋巴组织（GALT）中，位于滤泡相关上皮（FAE）下方的基质细胞大量表达Notch配体delta样1（Dll1）。在这里，我们表明，在肠道上皮细胞中缺乏Rbpj（一种参与Notch信号传导的转录因子编码基因）的小鼠，其GALT成熟存在缺陷。这种缺陷可归因于杯状细胞的扩张，这导致FAE中CCL20的下调。这些数据表明，由基质细胞维持的上皮Notch信号传导通过限制FAE中的分泌细胞分化，有助于GALT的完全成熟。
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