Research Center for Allergy and Immunology, RIKEN Yokohama Tsurumi, Yokohama, Japan.
Adv Immunol. 2010;107:153-85. doi: 10.1016/B978-0-12-381300-8.00006-X.
Since its discovery more than four decades ago, immunoglobulin (Ig) A has been the subject of continuous and intensive studies. The major concepts derived were that the precursors of IgA plasma cells are generated in follicular organized structures with the help of T cells and the secreted IgAs provide protection against mucosal pathogens. However, only recently we began to appreciate that IgAs play key roles in regulation of bacterial communities in the intestine and that the repertoire of gut microbiota is closely linked to the proper functioning of the immune system. In this review, we highlight the complex and dynamic mutualistic relationships between bacteria and immune cells and discuss the sites and pathways leading to IgA synthesis in gut-associated lymphoid tissues (GALT).
自四十多年前发现以来，免疫球蛋白（Ig）A 一直是持续深入研究的主题。从中得出的主要概念是，在 T 细胞的帮助下，IgA 浆细胞的前体在滤泡组织结构中产生，分泌的 IgA 提供针对黏膜病原体的保护。然而，直到最近我们才开始意识到 IgA 在调节肠道细菌群落方面发挥着关键作用，并且肠道微生物组的组成与免疫系统的正常功能密切相关。在这篇综述中，我们强调了细菌和免疫细胞之间复杂而动态的共生关系，并讨论了导致肠道相关淋巴组织（GALT）中 IgA 合成的部位和途径。
