Zhang Zhen, Dong Biqin, Li Hao, Zhou Fan, Zhang Hao F, Sun Cheng
Department of Mechanical Engineering, Northwestern University , Evanston, Illinois 60208, USA.
Department of Biomedical Engineering, Northwestern University , Evanston, Illinois 60208, USA.
J Appl Phys. 2014 Oct 14;116(14):144501. doi: 10.1063/1.4897455. Epub 2014 Oct 8.
We present in this paper a systematic study of the distance dependent detection characteristics of the newly developed micro-ring resonator (MRR)-based ultrasonic detector for photoacoustic microscopy (PAM). A simple analytic model was first developed to study the steady-state response to the continuous ultrasonic waves. While placing the MRR detector at the acoustic far-field provides longer working distance and broader field of view, the detection at acoustic near-field offers the improved sensitivity and broader bandwidth but at the cost of reduction in the field of view. Furthermore, a numerical model was developed to analyze the transient response to the photoacoustic-induced impulsive waves. Notably, far-field detection exhibits a flat wavefront of its response pattern in the time domain while large distortions are clearly visible in the case of near-field detection. Finally, both analytic and numerical models are validated by experimental studies. This work establishes a theoretical framework for quantitatively analyzing the trade-offs between near-field and far-field detection using MRR detector, creating a guideline for optimizing the PAM for various applications in biomedical imaging and diagnostics.
在本文中,我们对新开发的基于微环谐振器(MRR)的光声显微镜(PAM)超声探测器的距离依赖性检测特性进行了系统研究。首先建立了一个简单的解析模型来研究对连续超声波的稳态响应。虽然将MRR探测器置于声学远场可提供更长的工作距离和更宽的视野,但在声学近场进行检测可提高灵敏度和拓宽带宽,不过代价是视野减小。此外,还建立了一个数值模型来分析对光声诱导脉冲波的瞬态响应。值得注意的是,远场检测在时域中的响应模式呈现出平坦的波前,而近场检测的情况下则明显可见大的失真。最后,通过实验研究对解析模型和数值模型都进行了验证。这项工作建立了一个理论框架,用于定量分析使用MRR探测器在近场和远场检测之间的权衡,为优化用于生物医学成像和诊断中各种应用的PAM创建了指导方针。