Jang Hyung-Deok, Kim Do Hoon, Han Kyungdo, Ha Suk Gyu, Kim Yang Hyun, Kim Jae Woo, Park Ji Young, Yoon Su Jung, Jung Dong Wook, Park Sang Woon, Nam Ga Eun
a Department of Family Medicine , Korea University College of Medicine , Seoul , South Korea .
b Department of Biostatistics , Catholic University College of Medicine , Seoul , South Korea , and.
Curr Eye Res. 2015;40(10):1008-17. doi: 10.3109/02713683.2014.975367. Epub 2014 Nov 7.
To examine the associations of various parameters of obesity including adiposity with intraocular pressure (IOP) using nationally representative data of South Korean adults.
This cross-sectional study analyzed the data from the 2008-2010 Korea National Health and Nutrition Examination Survey. A total of 15,271 subjects (6600 men and 8671 women) participated. Body mass index (BMI), waist circumference (WC), total body fat mass, and total and regional body fat percentage were measured as parameters of obesity.
IOP showed positive linear associations with BMI, WC, total fat mass, and total and regional body fat percentages in men, and with BMI, WC, total fat mass, and trunk fat percentage in women after adjusting for confounding variables. Men with higher BMI, WC, total fat mass, and total and regional body fat percentages exhibited increasing trends in odd ratios for having IOP ≥ 18 mmHg after adjusting for all confounding factors (p for trend <0.001 for BMI and total fat mass; p for trend = 0.038 for WC; 0.003 for total body fat percentage; 0.002 for trunk fat percentage; 0.004 for leg fat percentage). However, only BMI showed a significantly increasing trend in the risk of IOP ≥18 mmHg in women.
In addition to BMI, WC and total fat mass, total and regional body fat percentage in men and trunk fat percentage in women are positively associated with IOP. Increased BMI, WC, and total and regional body fat are positively associated with a risk of higher IOP (IOP ≥18 mmHg), especially in Korean men.
利用韩国成年人具有全国代表性的数据,研究包括肥胖度在内的各种肥胖参数与眼压(IOP)之间的关联。
这项横断面研究分析了2008 - 2010年韩国国家健康与营养检查调查的数据。共有15271名受试者(6600名男性和8671名女性)参与。测量了体重指数(BMI)、腰围(WC)、全身脂肪量以及全身和局部体脂百分比作为肥胖参数。
在调整混杂变量后,男性的眼压与BMI、WC、总脂肪量以及全身和局部体脂百分比呈正线性关联,女性的眼压与BMI、WC、总脂肪量以及躯干脂肪百分比呈正线性关联。在调整所有混杂因素后,BMI、WC、总脂肪量以及全身和局部体脂百分比较高的男性,眼压≥18 mmHg的比值比呈上升趋势(BMI和总脂肪量的趋势p<0.001;WC的趋势p = 0.038;全身脂肪百分比的趋势p = 0.003;躯干脂肪百分比的趋势p = 0.002;腿部脂肪百分比的趋势p = 0.004)。然而,只有BMI在女性眼压≥18 mmHg的风险中显示出显著的上升趋势。
除BMI外,男性的WC和总脂肪量、全身和局部体脂百分比以及女性的躯干脂肪百分比与眼压呈正相关。BMI、WC以及全身和局部体脂增加与较高眼压(IOP≥18 mmHg)风险呈正相关,尤其是在韩国男性中。