Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
PLoS One. 2023 May 17;18(5):e0285759. doi: 10.1371/journal.pone.0285759. eCollection 2023.
To investigate the effect of change in body mass index (BMI) on intraocular pressure (IOP) in a large cohort of apparently healthy volunteers who underwent an annual comprehensive screening examinations.
This study included individuals who were enrolled in the Tel Aviv Medical Center Inflammation Survey (TAMCIS) and had IOP and BMI measurements at their baseline and follow up visits. Relationships between BMI and IOP and the effect of change in BMI on IOP were investigated.
A total of 7,782 individuals had at least one IOP measurement at their baseline visit, and 2,985 individuals had ≥2 visits recorded. The mean (SD) IOP (right eye) was 14.6 (2.5) mm Hg and mean (SD) BMI was 26.4 (4.1) kg/m2. IOP positively correlated with BMI levels (r = 0.16, p<0.0001). For individuals with morbid obesity (BMI≥35 kg/m2) and ≥2 visits, a change in BMI between the baseline and first follow-up visits correlated positively with a change in the IOP (r = 0.23, p = 0.029). Subgroup analysis of subjects who had a reduction of at least 2 BMI units showed a stronger positive correlation between change in BMI and change in IOP (r = 0.29, p<0.0001). For this subgroup, a reduction of 2.86 kg/m2 of BMI was associated with a reduction of 1 mm Hg in IOP.
BMI loss correlated with reduction in IOP, and this correlation was more pronounced among morbidly obese individuals.
在接受年度综合筛查检查的大量貌似健康志愿者中，研究体重指数（BMI）变化对眼内压（IOP）的影响。
本研究纳入了参加特拉维夫医疗中心炎症调查（TAMCIS）的个体，并在基线和随访时测量了他们的 IOP 和 BMI。研究了 BMI 与 IOP 之间的关系，以及 BMI 变化对 IOP 的影响。
共有 7782 人在基线就诊时有至少一次 IOP 测量，2985 人记录了≥2 次就诊。右眼平均（SD）IOP 为 14.6（2.5）mmHg，平均（SD）BMI 为 26.4（4.1）kg/m2。IOP 与 BMI 水平呈正相关（r=0.16，p<0.0001）。对于患有病态肥胖（BMI≥35 kg/m2）和≥2 次就诊的个体，基线和第一次随访之间 BMI 的变化与 IOP 的变化呈正相关（r=0.23，p=0.029）。对 BMI 降低至少 2 个单位的受试者进行亚组分析显示，BMI 变化与 IOP 变化之间存在更强的正相关（r=0.29，p<0.0001）。对于这个亚组，BMI 降低 2.86 kg/m2 与 IOP 降低 1 mmHg 相关。
BMI 下降与 IOP 降低相关，而在病态肥胖个体中，这种相关性更为显著。
