Patel Nimisha, Kellezi Blerina, Williams Amanda C de C
School of Psychology, University of East London, Romford Road, Stratford, London, UK, E15 4LZ.
Cochrane Database Syst Rev. 2014 Nov 11;2014(11):CD009317. doi: 10.1002/14651858.CD009317.pub2.
BACKGROUND: Torture is widespread, with potentially broad and long-lasting impact across physical, psychological, social and other areas of life. Its complex and diverse effects interact with ethnicity, gender, and refugee experience. Health and welfare agencies offer varied rehabilitation services, from conventional mental health treatment to eclectic or needs-based interventions. This review is needed because relatively little outcome research has been done in this field, and no previous systematic review has been conducted. Resources are scarce, and the challenges of providing services can be considerable. OBJECTIVES: To assess beneficial and adverse effects of psychological, social and welfare interventions for torture survivors, and to compare these effects with those reported by active and inactive controls. SEARCH METHODS: Randomised controlled trials (RCTs) were identified through a search of PsycINFO, MEDLINE, EMBASE, Web of Science, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Depression, Anxiety and Neurosis Specialised Register (CCDANCTR), the Latin American and Caribbean Health Science Information Database (LILACS), the Open System for Information on Grey Literature in Europe (OpenSIGLE), the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) and Published International Literature On Traumatic Stress (PILOTS) all years to 11 April 2013; searches of Cochrane resources, international trial registries and the main biomedical databases were updated on 20 June 2014. We also searched the Online Library of Dignity (Danish Institute against Torture), reference lists of reviews and included studies and the most frequently cited journals, up to April 2013 but not repeated for 2014. Investigators were contacted to provide updates or details as necessary. SELECTION CRITERIA: Full publications of RCTs or quasi-RCTs of psychological, social or welfare interventions for survivors of torture against any active or inactive comparison condition. DATA COLLECTION AND ANALYSIS: We included all major sources of grey literature in our search and used standard methodological procedures as expected by The Cochrane Collaboration for collecting data, evaluating risk of bias and using GRADE (Grades of Recommendation, Assessment, Development and Evaluation) methods to assess the quality of evidence. MAIN RESULTS: Nine RCTs were included in this review. All were of psychological interventions; none provided social or welfare interventions. The nine trials provided data for 507 adults; none involved children or adolescents. Eight of the nine studies described individual treatment, and one discussed group treatment. Six trials were conducted in Europe, and three in different African countries. Most people were refugees in their thirties and forties; most met the criteria for post-traumatic stress disorder (PTSD) at the outset. Four trials used narrative exposure therapy (NET), one cognitive-behavioural therapy (CBT) and the other four used mixed methods for trauma symptoms, one of which included reconciliation methods. Five interventions were compared with active controls, such as psychoeducation; four used treatment as usual or waiting list/no treatment; we analysed all control conditions together. Duration of therapy varied from one hour to longer than 20 hours with a median of around 12 to 15 hours. All trials reported effects on distress and on PTSD, and two reported on quality of life. Five studies followed up participants for at least six months.No immediate benefits of psychological therapy were noted in comparison with controls in terms of our primary outcome of distress (usually depression), nor for PTSD symptoms, PTSD caseness, or quality of life. At six-month follow-up, three NET and one CBT study (86 participants) showed moderate effect sizes for intervention over control in reduction of distress (standardised mean difference (SMD) -0.63, 95% confidence interval (CI) -1.07 to -0.19) and of PTSD symptoms (SMD -0.52, 95% CI -0.97 to -0.07). However, the quality of evidence was very low, and risk of bias resulted from researcher/therapist allegiance to treatment methods, effects of uncertain asylum status of some people and real-time non-standardised translation of assessment measures. No measures of adverse events were described, nor of participation, social functioning, quantity of social or family relationships, proxy measures by third parties or satisfaction with treatment. Too few studies were identified for review authors to attempt sensitivity analyses. AUTHORS' CONCLUSIONS: Very low-quality evidence suggests no differences between psychological therapies and controls in terms of immediate effects on post-traumatic symptoms, distress or quality of life; however, NET and CBT were found to confer moderate benefits in reducing distress and PTSD symptoms over the medium term (six months after treatment). Evidence was of very low quality, mainly because non-standardised assessment methods using interpreters were applied, and sample sizes were very small. Most eligible trials also revealed medium to high risk of bias. Further, attention to the cultural appropriateness of interventions or to their psychometric qualities was inadequate, and assessment measures used were unsuitable. As such, these findings should be interpreted with caution.No data were available on whether symptom reduction enabled improvements in quality of life, participation in community life, or in social and family relationships in the medium term. Details of adverse events and treatment satisfaction were not available immediately after treatment nor in the medium term. Future research should aim to address these gaps in the evidence and should include larger sample sizes when possible. Problems of torture survivors need to be defined far more broadly than by PTSD symptoms, and recognition given to the contextual influences of being a torture survivor, including as an asylum seeker or refugee, on psychological and social health.
背景:酷刑普遍存在,可能在身体、心理、社会和生活的其他领域产生广泛而持久的影响。其复杂多样的影响与种族、性别和难民经历相互作用。健康和福利机构提供各种康复服务,从传统的心理健康治疗到折衷或基于需求的干预措施。进行这项综述是因为该领域相对较少开展结局研究,且此前尚未进行过系统综述。资源稀缺,提供服务面临的挑战可能相当大。 目的:评估针对酷刑幸存者的心理、社会和福利干预措施的有益和不利影响,并将这些影响与主动和非主动对照所报告的影响进行比较。 检索方法:通过检索以下数据库识别随机对照试验(RCT):PsycINFO、MEDLINE、EMBASE、科学网、护理及相关健康文献累积索引(CINAHL)、Cochrane对照试验中心注册库(CENTRAL)、Cochrane抑郁、焦虑和神经症专业注册库(CCDANCTR)、拉丁美洲和加勒比健康科学信息数据库(LILACS)、欧洲灰色文献信息开放系统(OpenSIGLE)、世界卫生组织国际临床试验注册平台(WHO ICTRP)以及创伤应激国际已发表文献(PILOTS),检索截至2013年4月11日的所有年份文献;2014年6月20日更新了对Cochrane资源、国际试验注册库和主要生物医学数据库进行的检索。我们还检索了尊严在线图书馆(丹麦反酷刑协会)、综述及纳入研究的参考文献列表以及最常被引用的期刊,检索截至2013年4月,但2014年未重复检索。必要时与研究者联系以获取更新信息或详细内容。 选择标准:针对酷刑幸存者的心理、社会或福利干预措施的RCT或准RCT的完整出版物,与任何主动或非主动对照条件进行比较。 数据收集与分析:我们在检索中纳入了所有主要的灰色文献来源,并采用Cochrane协作网预期的标准方法程序来收集数据、评估偏倚风险以及使用GRADE(推荐分级、评估、制定与评价)方法评估证据质量。 主要结果:本综述纳入了9项RCT。所有研究均为心理干预;无社会或福利干预措施的研究。这9项试验为507名成年人提供了数据;无涉及儿童或青少年的研究。9项研究中的8项描述了个体治疗,1项讨论了团体治疗。6项试验在欧洲进行;3项在不同的非洲国家进行。大多数人是三四十岁的难民;大多数人一开始就符合创伤后应激障碍(PTSD)的标准。4项试验使用了叙事暴露疗法(NET),1项使用认知行为疗法(CBT),另外4项对创伤症状采用了混合方法,其中1项包括和解方法。5项干预措施与主动对照(如心理教育)进行了比较;4项采用常规治疗或等待名单/不治疗;我们将所有对照条件合并分析。治疗时长从1小时到超过20小时不等,中位数约为12至15小时。所有试验均报告了对痛苦和PTSD的影响,2项报告了生活质量。5项研究对参与者进行了至少6个月的随访。就我们的主要结局痛苦(通常为抑郁)而言,与对照相比,未发现心理治疗有直接益处,对于PTSD症状、PTSD病例状态或生活质量也未发现有直接益处。在6个月随访时,3项NET研究和1项CBT研究(86名参与者)显示,干预组在减轻痛苦(标准化均数差(SMD) -0.63,95%置信区间(CI) -1.07至 -0.19)和PTSD症状(SMD -0.52,95% CI -0.97至 -0.07)方面,与对照组相比有中等效应量。然而,证据质量非常低,偏倚风险源于研究者/治疗师对治疗方法的偏好、部分人不确定的庇护身份的影响以及评估措施的实时非标准化翻译。未描述不良事件的测量,也未提及参与度、社会功能、社会或家庭关系数量、第三方代理测量或治疗满意度。纳入综述的研究数量过少,以至于综述作者无法进行敏感性分析。 作者结论:质量极低的证据表明,心理治疗与对照在对创伤后症状、痛苦或生活质量的直接影响方面无差异;然而,发现NET和CBT在中期(治疗后6个月)减轻痛苦和PTSD症状方面有中等益处。证据质量非常低,主要是因为使用了使用口译员的非标准化评估方法,且样本量非常小。大多数符合条件的试验还显示有中到高的偏倚风险。此外,对干预措施的文化适宜性或其心理测量质量的关注不足,所使用的评估措施不合适。因此,这些发现应谨慎解读。关于症状减轻是否能在中期改善生活质量、参与社区生活或社会及家庭关系,尚无数据。治疗后及中期均无不良事件和治疗满意度的详细信息。未来研究应旨在填补这些证据空白,并尽可能纳入更大样本量。酷刑幸存者的问题需要比PTSD症状更广泛地定义,并且应认识到作为酷刑幸存者(包括作为寻求庇护者或难民)的背景因素对心理和社会健康的影响。
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