Liberty Hyde Bailey Emeritus Professor, Cornell University, Ithaca, New York 14853.
Annu Rev Anim Biosci. 2013 Jan;1:1-20. doi: 10.1146/annurev-animal-031412-103722. Epub 2012 Dec 13.
In 1946, at the end of World War II, I entered graduate school at Cornell University, where I remained for 44 years. During that time, my laboratory produced more than 300 publications in the field of reproductive biology, including studies on nutrition and reproduction, the role of the hypothalamus in pituitary gonadotropin release, corpus luteum formation and function, hormone assays, and estrous cycle synchronization. At age seventy, I retired from Cornell and accepted the Gordon Cain Endowed Professorship at Louisiana State University, where I continued my work on the bovine corpus luteum and added research on the collection, maturation, in vitro fertilization, and culture of bovine oocytes. In 1994, I moved to the Pennington Biomedical Research Center and soon thereafter started the research that led to development of the lytic peptide-gonadotropin conjugates, which target and destroy cancer cell membranes. I am continuing my work on the development of targeted cancer cell drugs and, yes, research is still fun!
1946 年,第二次世界大战结束后,我进入康奈尔大学研究生院,在那里待了 44 年。在那段时间里,我的实验室在生殖生物学领域发表了 300 多篇论文,包括营养与生殖、下丘脑在垂体促性腺激素释放中的作用、黄体形成和功能、激素测定以及发情周期同步等方面的研究。70 岁时,我从康奈尔大学退休,接受了路易斯安那州立大学戈登·凯恩(Gordon Cain)教授的职位,继续研究牛的黄体,并增加了对牛卵母细胞的收集、成熟、体外受精和培养的研究。1994 年,我搬到彭宁顿生物医学研究中心,此后不久开始了导致溶瘤肽-促性腺激素缀合物研发的研究,该缀合物靶向并破坏癌细胞膜。我正在继续开发针对癌细胞的药物的研究,是的,研究仍然很有趣!