EVpedia：一个用于细胞外囊泡研究的社区网络门户。
EVpedia: a community web portal for extracellular vesicles research.
作者信息
Kim Dae-Kyum, Lee Jaewook, Kim Sae Rom, Choi Dong-Sic, Yoon Yae Jin, Kim Ji Hyun, Go Gyeongyun, Nhung Dinh, Hong Kahye, Jang Su Chul, Kim Si-Hyun, Park Kyong-Su, Kim Oh Youn, Park Hyun Taek, Seo Ji Hye, Aikawa Elena, Baj-Krzyworzeka Monika, van Balkom Bas W M, Belting Mattias, Blanc Lionel, Bond Vincent, Bongiovanni Antonella, Borràs Francesc E, Buée Luc, Buzás Edit I, Cheng Lesley, Clayton Aled, Cocucci Emanuele, Dela Cruz Charles S, Desiderio Dominic M, Di Vizio Dolores, Ekström Karin, Falcon-Perez Juan M, Gardiner Chris, Giebel Bernd, Greening David W, Gross Julia Christina, Gupta Dwijendra, Hendrix An, Hill Andrew F, Hill Michelle M, Nolte-'t Hoen Esther, Hwang Do Won, Inal Jameel, Jagannadham Medicharla V, Jayachandran Muthuvel, Jee Young-Koo, Jørgensen Malene, Kim Kwang Pyo, Kim Yoon-Keun, Kislinger Thomas, Lässer Cecilia, Lee Dong Soo, Lee Hakmo, van Leeuwen Johannes, Lener Thomas, Liu Ming-Lin, Lötvall Jan, Marcilla Antonio, Mathivanan Suresh, Möller Andreas, Morhayim Jess, Mullier François, Nazarenko Irina, Nieuwland Rienk, Nunes Diana N, Pang Ken, Park Jaesung, Patel Tushar, Pocsfalvi Gabriella, Del Portillo Hernando, Putz Ulrich, Ramirez Marcel I, Rodrigues Marcio L, Roh Tae-Young, Royo Felix, Sahoo Susmita, Schiffelers Raymond, Sharma Shivani, Siljander Pia, Simpson Richard J, Soekmadji Carolina, Stahl Philip, Stensballe Allan, Stępień Ewa, Tahara Hidetoshi, Trummer Arne, Valadi Hadi, Vella Laura J, Wai Sun Nyunt, Witwer Kenneth, Yáñez-Mó María, Youn Hyewon, Zeidler Reinhard, Gho Yong Song
机构信息
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Section of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, NY, USA, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, INSERM, UMR837 JEAN-PIERRE Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, BIO21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, UK, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, MA, USA, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai M
出版信息
Bioinformatics. 2015 Mar 15;31(6):933-9. doi: 10.1093/bioinformatics/btu741. Epub 2014 Nov 10.
MOTIVATION
Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging.
RESULTS
We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.
AVAILABILITY AND IMPLEMENTATION
The web site was implemented in PHP, Java, MySQL and Apache, and is freely available at http://evpedia.info.
动机
细胞外囊泡（EVs）是具有双层膜结构的球形蛋白脂质体，包含各种生物活性分子。由于囊泡命名法和成分的复杂性，目前在线搜索与EV相关的出版物和囊泡成分具有挑战性。
结果
我们展示了EVpedia的改进版本，这是一个用于EV研究的公共数据库。这个社区门户网站包含出版物数据库、囊泡成分、直系同源囊泡成分的识别、生物信息学工具和个性化功能。EVpedia包括6879篇出版物、来自263个高通量数据集的172080个囊泡成分，已被来自750多个城市的65000多人访问。此外，来自73个国际研究小组的约350名成员参与了EVpedia的开发。这个基于网络的免费数据库可能是促进新兴的EV研究领域的有用资源。
可用性和实现方式
该网站用PHP、Java、MySQL和Apache实现，可在http://evpedia.info免费获取。
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